Set 1

Question 1

pharmacology def

Answer 1

science of interactions of chemical compounds with biological systems

Question 2

pharmacodynamics def

Answer 2

the study of the biochemical and physiological effects of drugs and mechanisms of their actions, including the correlation of their actions and effects with their chemical structure

Question 3

pharmacokinetics def

Answer 3

the study of the absorption, distribution, biotransformation, and elimination of xenobiotics

Question 4

nature of the drugs is defined by

Answer 4

actions (agonist or antagonist)

Question 5

T/F the drug receptor is the cornerstone of pharmacology

Answer 5

True

Question 6

What interacts with the receptor to stimulate a biological response

Answer 6

agonist

Question 7

what are the most basic pharmacodynamic principles

Answer 7

D+R-DR-Effect
D+R-DRcomplex-effector mol-effect
D+R-DRcomplex-couple mol-effector mol-effect

Question 8

what is the first step of the pharmacodynamic principles

Answer 8

drugs bind

Question 9

what kinds of interactions do drugs have

Answer 9

orthosteric-agonists and allosteric-PAM/NAM

Question 10

T/F there is only 1 orthosteric site but many allosteric sites

Answer 10

true

Question 11

on a graph

Answer 11

full agonist-highest line
partial agonist-middle line
antagonist- straight xaxis line
inverse agonist-below xaxis line

Question 12

T/F inhibitors of metabolism or reuptake of endogenous ligands have drug like responses

Answer 12

true

Question 13

to produce the characteristic effects of the drug being used what does the drug do

Answer 13

the drug must achieve adequate concentration at its site of action

Question 14

T/F drugs have one effect

Answer 14

FALSE drugs will have many effects

Question 15

high affinity causes the drugs to bind ___ and leave __

Answer 15

fast, slow

Question 16

low affinity causes the drugs to bind ___ and leave __

Answer 16

slow, fast

Question 17

acute effects

Answer 17

are fine

Question 18

chronic effects

Answer 18

resistence

Question 19

drugs modify

Answer 19

the normal physiological or biochemical function

Question 20

therapeutic effect

Answer 20

drugs are desired to have only one effect which is not true

Question 21

toxic/side effects

Answer 21

unwanted effects usually at higher doses

Question 22

what are the sites of drug actions

Answer 22

extracellular, intracellular, on cell surface (most)

Question 22

extracellular sites

Answer 22

are neutralization of excessive gastric acid by antacids

Question 23

intracellular sites

Answer 23

treat infections, cancer chemo, hormones

Question 24

cell surface sites

Answer 24

combining with receptors, nicotine, growth factors, monoclonal antibodies

Question 25

intracellular sites have to penetrate what

Answer 25

the cell membrane and be unionized

Question 26

T/F most receptors are proteins

Answer 26

true

Question 27

agonists bind to a receptor and

Answer 27

stimulate a biological response

Question 28

antagonists bind to receptors and

Answer 28

do not stimulate a response

Question 29

T/F antagonist block another receptor from binding

Answer 29

True

Question 30

concentrations may be reached and no further increase a response is what

Answer 30

saturation

Question 31

10-90 3 log rule

Answer 31

10-50-90 percent

Question 32

10^-3

Answer 32

milimolar

Question 33

10^-6

Answer 33

micromolar

Question 34

10^-9

Answer 34

nanomolar

Question 35

10^-12

Answer 35

picomolar

Question 36

KD is a measure of what

Answer 36

affinity
low KD=tight=high affinity

Question 37

dissociation constant equations

Answer 37

(D)(R)/(DR)=KD
50% Vmax=KD

Question 38

Cheng-Prusoff equation

Answer 38

Ki=IC50/[1+(L/KD)]

Question 39

What is not required to calculate Ki from the cheng-prusoff equation

Answer 39

bmax

Question 40

T/F allosteric modulators have both positive and negative effects on agonists

Answer 40

true

Question 41

Which statements regarding Bmax is not true
A. Bmax is # of receptors
B. Bmax is determined through saturation
C. Bmax is not regulated by drug treatment
D. Bmax is independent of ligand
E. Bman can influence downstream signalling

Answer 41

C