Serotonin

Question 1

General Info

Answer 1

• Also called 5-HT
• Made from tryptophan
• Affects mood, aggression, feeding, sleep
• At least 18 receptors (most are metabotropic)

Question 2

Synthesis

Answer 2

• Synthesis in midbrain, pons, medulla in neurons of raphe nuclei in reticular formation
• Median rapher-> cerebral cortex/HPC (cognitive functions)
• Dorsal raphe-> basal ganglia/cerebellum (motor control)
• Dorsal raphe-> cerebral cortex/ HPC

Question 3

Fluoxetine:

Answer 3

• Selective serotonin reuptake inhibitor (SSRI)

* Active component of Prozac, used to treat depression, anxiety OCD

Question 4

Fenfluramine:

Answer 4

• Both reuptake inhibitor and stimulates release
• Appetite suppressant- formerly used to treat obesity
• Discontinued because of heart disease