Serotonin Flashcards

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1
Q

General Info

A
  • Also called 5-HT
  • Made from tryptophan
  • Affects mood, aggression, feeding, sleep
  • At least 18 receptors (most are metabotropic)
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2
Q

Synthesis

A
  • Synthesis in midbrain, pons, medulla in neurons of raphe nuclei in reticular formation
  • Median rapher-> cerebral cortex/HPC (cognitive functions)
  • Dorsal raphe-> basal ganglia/cerebellum (motor control)
  • Dorsal raphe-> cerebral cortex/ HPC
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3
Q

Fluoxetine:

A
  • Selective serotonin reuptake inhibitor (SSRI)

* Active component of Prozac, used to treat depression, anxiety OCD

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4
Q

Fenfluramine:

A
  • Both reuptake inhibitor and stimulates release
  • Appetite suppressant- formerly used to treat obesity
  • Discontinued because of heart disease
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