Dopamine Flashcards
1
Q
Synthesis
A
• Synthesized in mesencephalon (midbrain) in the substantia nigra and ventral tegmental area
2
Q
Nigrostriatal Pathway
A
o Substantial Nigra-> striatum
Movement
3
Q
Mesolimbic pathway
A
o Ventral tegmental area-> limbic system (motivational behavior and reward)
Learning
4
Q
Mesocortical Pathway
A
o Ventral tegmental area-> prefrontal cortex (higher cognitive functions)
Attention and Learning
5
Q
Parkinson’s Disease:
A
- L-Dopa used to treat Parkinson’s because it can cross blood brain barrier
- Limited efficacy because of side effects, negative feedback
6
Q
Subfamilies:
A
- D1 Like- D1, D5
* D2 like- D2,3,4
7
Q
Amphetamines
A
o Agonist, blocks reuptake of dopamine
o Not specific, also enhances norepinephrine
o Helps with disorders of excessive sleep
8
Q
Antischizophrenic (Antipsychotic drugs)
A
o Antagonists, blocks D2 receptors
o i.e. Haloperidol
o Can cause motor side effects (one neurotransmitter has many functions)
