GABA Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

GABA

A
  • Inhibitory amino acid neurotransmitter
  • Synthesized from glutamate (not found in glutamaterigic cell or would glutmatae would turn into GABA)
  • Found in brain and spinal chord (same places as glutamate)
  • Reduced GABA causes brain hyperactivity (seizures)
  • Not localized
  • Helps coordinate processing functions
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2
Q

GABA (A) Receptor

A
o	Ionotropic for Cl
o	5 subunits
   o	Benzodiazepine site
   o	Steroid site
   o	GABA site
   o	Picrotoxin site
   o	Barbiturate and alcohol site
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3
Q

GABA (B) Receptor

A

o Metabotropic (less common)

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4
Q

Benzodiazepines:

A
  • Valium, Librium
  • Reduces anxiety (anxiolytic), muscle relaxant, anti convulsant
  • Can be used as immediate response to seizures
  • Impairs learning and memory
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5
Q

Barbiturates:

A
  • Calming
  • More extreme effects than benzodiazepines
  • Can be used as anesthesia, but not very much because small window between anesthesia and death
  • Impairs learning and memory
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6
Q

Steroids:

A
  • Calming
  • i.e. progesterone
  • Restores homeostasis after stressful situation
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7
Q

Picrotoxin:

A
  • Poison found in East Indian shrub
  • Dampens effects of GABA
  • Causes seizures and convulsions at high doses
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8
Q

Alcohol:

A
  • Regulates GABA function at benzodiazepine or barbiturate site
  • Not really understood because it’s a simple molecule
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