Serotonin

Question 1

Serotonin Effect (Vascular)

Answer 1

Vasoconstriction Large Vessels
Vasodilation Arterioles

Question 2

Serotonin Physiological Effect (Smooth Muscle, GI, Platelet, Nociceptive)

Answer 2

Bronchi Constriction

Increase GI Motility

Platelet Aggregation

Simulates peripheral nociceptive nerve endings

Question 3

Serotonin Pathophysiological Effect

Answer 3

Migraine
Carcinoid Syndrome
Nausea
Mood Disorder + Anxiety

Question 4

Sumatriptan

Answer 4

5-HT1(BDF) Receptor Agonist
Acute Use

• Inhibits Trigeminal Nerve –> Decreases Inflammatory Peptide Release
• Constricts Cerebral Arteries –> Decreases Blood Flow

Side Effects: Dysrhythmia, Coronary Vasoconstriction

Question 5

Almotriptan

Answer 5

5-HT1(BDF) Receptor Agonist
Acute Use

• Inhibits Trigeminal Nerve –> Decreases Inflammatory Peptide Release
• Constricts Cerebral Arteries –> Decreases Blood Flow

Side Effects: Dysrhythmia, Coronary Vasoconstriction

Less Side Effects than Sumatriptan

Question 6

Pizotifen

Answer 6

5-HT2 Receptor Antagonist
Prophylaxis Use (Preventative)

Prevents Constriction of Cerebral Arteries

Side Effects: Weight gain, Antimuscarinic, Sedation

Question 7

Cyproheptidine

Answer 7

5-HT2 Receptor Antagonist
Prophylaxis Use (Preventative)

Prevents Constriction of Cerebral Arteries
Controls Carcinoid Syndrome Symptoms

Side Effects: Weight gain, Antimuscarinic, Sedation

Question 8

5-HT 1B

Answer 8

Gi
Pulmonary Vasoconstriction (Lung)
Presynaptic Inhibition (CNS)

Question 9

5-HT 1D

Answer 9

Locomotion (CNS)
Cerebral Vasoconstriction (Blood Vessels)

Question 10

5-HT 2A

Answer 10

Gq

Neuronal Excitation (CNS)
Platelet Aggregation (Platelets)
Smooth Muscle Contraction (Smooth Muscles)
Vasoconstriction/dilation

Question 11

5-HT 3

Answer 11

Ligand-Gated Cation Channel

Neuronal Excitation (Autonomic / Nociceptive Neurons)
Anxiety
Emesis