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PHARM 203 Drugs (1st Midterm) > Eicosanoids & Cannabinoid > Flashcards

Eicosanoids & Cannabinoid Flashcards

1
Q

Arachidonic Acid

A

Made from phospholipids by Phospholipase A2

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2
Q

Prostanoids

A

Formed from Arachidonic Acid

Eicosanoids that play an important role in inflammation

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3
Q

COX-1

A

Constitutive

Converts AA into Prostanoid

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4
Q

COX-2

A

Inducible

Converts AA into Prostanoid

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5
Q

NSAIDS

A

Non Selective Cox Inhibitor

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6
Q

PGH2

A

Precursor Prostaglandin

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7
Q

Prostacyclin (PGI2)

A

Converted by Prostacyclin Synthase in Endothelium

Inhibits Platelet Aggregation
Vasodilator

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8
Q

Thromboxane (TXA2)

A

Converted by Thromboxane Synthase in Platelets

Stimulates Platelet Aggregation
Vasoconstrictor

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9
Q

PGD2

A

Vasodilation
Inhibits Platelet Aggregation

Relaxes GI and Uterus Muscles

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10
Q

PGE2

A

Main Inflammatory Prostanoid
Vasodilator

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11
Q

PGF2a

A

Uterine Contraction

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12
Q

Alprostadil

A

PGE1
Vasodilation

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13
Q

Misoprostol

A

PGE2
Inhibits Gastric Acid Secretion
Increases GI Muscous Secretion

Uterine Contractions (Terminate Early Pregnancy)
Cervical Ripening/Dilation (Induce Labour)

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14
Q

Gemeprost

A

Uterine Contractions (Terminate Early Pregnancy)

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15
Q

Dinoprostone

A

PGE2
Cervical Ripening/Dilation (Induce Labour)

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16
Q

Carboprost

A

PGF2a
Uterine Contraction (Uses Blood to Cause)

17
Q

Latanoprost

A

PGF2alpha
Uterine Contraction
Reduces Intraocular Pressure Eye (Tx Glaucoma)

18
Q

Epoprostenol

A

PGI2

Inhibits Platelet Aggregation
Vasodilation (Treats Hypertension)

19
Q

LTB4

A

BLT Receptor Agonist

Pro-Inflammatory Leukotriene

Stimulates Neutrophil Chemotaxis
Stimulates Proliferation
Stimulates Cytokine production

20
Q

Cysteinyl Leukotriene

A

CysLT Receptor Agonist

Contracts Bronchi Muscle
Vasodilation
Constriction in Cornea

21
Q

Zafirlukast

A

CysLT Receptor Antagonist

Treats Asthma (Inhibit Bronchoconstriction)

22
Q

Montelukast

A

CysLT Receptor Antagonist

Treats Asthma (Inhibit Bronchoconstriction)

23
Q

THC

A

Tetrahydrocannabinol

Psychoactive Compound in Cannabis

Vasodilation & Decreased Eye Pressure
Bronchodilation

Increased Appetite

More Sensory Awareness
Relaxation

Impaired Memory
Impaired Motor

24
Q

CBD

A

Cannabidiol

Non psychoactive compound in Cannabis

25
Q

Anandamide

A

Endocannabinoid

Retrograde Signaling
Nociception
Cardiovascular, Respiratory, GI
Appetite
Reproductive

26
Q

2-arachidonyl glycerol

A

Endocannabinoid

Retrograde Signaling
Nociception
Cardiovascular, Respiratory, GI
Appetite
Reproductive

27
Q

Nabiximols

A

CB Agonist
THC & CBD Combination

Used to treat pain

28
Q

Nabilone

A

CB Agonist
Synthetic Cannabinoid

Used to treat nausea and vomiting that occurs with chemotherapy

29
Q

CB1

A

Cannabinoid Receptors in Brain

30
Q

CB2

A

Cannabinoid Receptors in Immune Cells

PHARM 203 Drugs (1st Midterm) (8 decks)

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