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PHARM 203 Drugs (1st Midterm) > Noradrenergic > Flashcards

Noradrenergic Flashcards

1
Q

Noradrenaline Agonist Action

A

Alpha: Increase Heart Rate (Vasoconstriction)
Beta: Bronchodilation

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2
Q

Adrenaline Agonist Action

A

Alpha: Increase Heart Rate (Vasoconstriction)
Beta: Bronchodilation

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2
Q

Phenylephrine

A

Alpha 1 Agonist

Treats Nasal Decongestion (Vasoconstriction)

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2
Q

Salbutamol

A

Beta 2 Agonist

Treats Asthma (Bronchodilation)
Delays Premature Labour (Relaxes Uterus)

Unwanted Effect: Causes Tremors

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2
Q

Salmeterol

A

Beta 2 Agonist

Treats Asthma (Bronchodilation)
Unwanted Effect: Cause Tremors

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3
Q

Mirabegron

A

Beta 3 Agonist

Treats Overactive Bladder (Relaxes Bladder)

Side Effect: Increases Heart Rate

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3
Q

Phenoxybenzamine

A

Non-Selective Alpha Antagonist

Decreases Norepinephrine and epinephrine release
(Suppresses Adrenal tx Pheochromocytoma)

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4
Q

Prazosin

A

Alpha 1 Antagonist

Treats Hypertension (Inhibits Vasoconstriction)

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5
Q

Doxazosin

A

Alpha 1 Antagonist

Treats Hypertension (Inhibits Vasoconstriction)

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6
Q

Propranolol

A

Non-Selective Beta Antagonist

Beta 1: Decreases BP and Cardiac Output
–> Decrease Heart Work Load/Stress
(Treats Hypertension, Angina, Heart Failure)
Beta 2: Treats Tremors

Side Effects: Bronchoconstriction

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7
Q

Alprenolol

A

Non-Selective Beta Partial Antagonist

Beta 1: Decreases BP and Cardiac Output
–> Decrease Heart Work Load/Stress
(Treats Hypertension, Angina, Heart Failure)
Beta 2: Treats Tremors

Side Effects: Bronchoconstriction

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8
Q

Metoprolol

A

Beta 1 Antagonist

Decreases BP and Cardiac Output

Less Risk of Bronchoconstriction

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9
Q

Atenolol

A

Beta 1 Antagonist

Decreases BP and Cardiac Output
Less Risk of Bronchoconstriction

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10
Q

Nebivolol

A

Beta 1 Antagonist
Increases NO (Causes Vasodilation)

Decreases BP and Cardiac Output

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11
Q

Labetalol

A

Alpha/Beta antagonist

Treats Hypertension in pregnancy (Lowers BP)

Alpha Side Effects: Hypotension
Beta Side Effects: Bronchoconstriction

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12
Q

Carvedilol

A

Alpha1/Beta antagonist

Treats Heart Failure

Beta Side Effects: Bronchoconstriction

13
Q

a-methyl-tyrosine

A

Lowers NA Effects

Inhibits tyrosine hydroxylase
Inhibits NA and Adrenaline synthesis

Prevents adrenal gland tumour overactivation

14
Q

Methyldopa

A

Lowers NA Effects

Converted into Methyl-noradrenaline
Builds up and displaces noradrenaline in synaptic vesicles
Less active than NA on alpha 1 receptors

Not broken down by MAO

15
Q

L-DOPS

A

Increases NA

Prodrug
Acts like DOPA and is converted into NA

16
Q

Amphetamine

A

Increase NA Effect –> CNS Stimulant

Stimulates NA release
Inhibits NA reuptake

Increases NA concentration in synapse

17
Q

Ephedrine

A

Stimulates NA release
Beta Agonist

DECONGESTANT (Vasoconstriction)
NA acts on alpha adrenoceptors
Increase NA concentration in synapse

18
Q

Imipramine

A

Treats Depression

Blocks Norepinephrine Transporters (NET), inhibits NA reuptake
Anti-cholinergic effects

19
Q

Cocaine

A

CNS Stimulant
Local Anesthetic (Sometimes)

Blocks NET, inhibits NA reuptake

20
Q
A

PHARM 203 Drugs (1st Midterm) (8 decks)

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