Noradrenergic Flashcards
Noradrenaline Agonist Action
Alpha: Increase Heart Rate (Vasoconstriction)
Beta: Bronchodilation
Adrenaline Agonist Action
Alpha: Increase Heart Rate (Vasoconstriction)
Beta: Bronchodilation
Phenylephrine
Alpha 1 Agonist
Treats Nasal Decongestion (Vasoconstriction)
Salbutamol
Beta 2 Agonist
Treats Asthma (Bronchodilation)
Delays Premature Labour (Relaxes Uterus)
Unwanted Effect: Causes Tremors
Salmeterol
Beta 2 Agonist
Treats Asthma (Bronchodilation)
Unwanted Effect: Cause Tremors
Mirabegron
Beta 3 Agonist
Treats Overactive Bladder (Relaxes Bladder)
Side Effect: Increases Heart Rate
Phenoxybenzamine
Non-Selective Alpha Antagonist
Decreases Norepinephrine and epinephrine release
(Suppresses Adrenal tx Pheochromocytoma)
Prazosin
Alpha 1 Antagonist
Treats Hypertension (Inhibits Vasoconstriction)
Doxazosin
Alpha 1 Antagonist
Treats Hypertension (Inhibits Vasoconstriction)
Propranolol
Non-Selective Beta Antagonist
Beta 1: Decreases BP and Cardiac Output
–> Decrease Heart Work Load/Stress
(Treats Hypertension, Angina, Heart Failure)
Beta 2: Treats Tremors
Side Effects: Bronchoconstriction
Alprenolol
Non-Selective Beta Partial Antagonist
Beta 1: Decreases BP and Cardiac Output
–> Decrease Heart Work Load/Stress
(Treats Hypertension, Angina, Heart Failure)
Beta 2: Treats Tremors
Side Effects: Bronchoconstriction
Metoprolol
Beta 1 Antagonist
Decreases BP and Cardiac Output
Less Risk of Bronchoconstriction
Atenolol
Beta 1 Antagonist
Decreases BP and Cardiac Output
Less Risk of Bronchoconstriction
Nebivolol
Beta 1 Antagonist
Increases NO (Causes Vasodilation)
Decreases BP and Cardiac Output
Labetalol
Alpha/Beta antagonist
Treats Hypertension in pregnancy (Lowers BP)
Alpha Side Effects: Hypotension
Beta Side Effects: Bronchoconstriction
Carvedilol
Alpha1/Beta antagonist
Treats Heart Failure
Beta Side Effects: Bronchoconstriction
a-methyl-tyrosine
Lowers NA Effects
Inhibits tyrosine hydroxylase
Inhibits NA and Adrenaline synthesis
Prevents adrenal gland tumour overactivation
Methyldopa
Lowers NA Effects
Converted into Methyl-noradrenaline
Builds up and displaces noradrenaline in synaptic vesicles
Less active than NA on alpha 1 receptors
Not broken down by MAO
L-DOPS
Increases NA
Prodrug
Acts like DOPA and is converted into NA
Amphetamine
Increase NA Effect –> CNS Stimulant
Stimulates NA release
Inhibits NA reuptake
Increases NA concentration in synapse
Ephedrine
Stimulates NA release
Beta Agonist
DECONGESTANT (Vasoconstriction)
NA acts on alpha adrenoceptors
Increase NA concentration in synapse
Imipramine
Treats Depression
Blocks Norepinephrine Transporters (NET), inhibits NA reuptake
Anti-cholinergic effects
Cocaine
CNS Stimulant
Local Anesthetic (Sometimes)
Blocks NET, inhibits NA reuptake
