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PHARM 203 Drugs (1st Midterm) > Peptides > Flashcards

Peptides Flashcards

1
Q

Substance P (SP)

A

Neuropeptide

Can active mast cells to release histamine.
When released from peripheral endings of nociceptive sensory neurons it can cause:

Neurogenic Inflammation
Causes pain like headaches

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2
Q

Neurokinin A (NkA)

A

Neuropeptide

Can active mast cells to release histamine.
When released from peripheral endings of nociceptive sensory neurons it can cause:

Neurogenic Inflammation
Causes pain like headaches

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3
Q

Calcitonin Gene-Related Peptide (CGRP)

A

Neuropeptide

Can active mast cells to release histamine.
When released from peripheral endings of nociceptive sensory neurons it can cause:

Neurogenic Inflammation
Causes pain like headaches

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4
Q

Neuropeptide Y

A

Neuropeptide

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5
Q

Erenumab

A

Monoclonal Antibody against CGRP

Treats Migraines

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6
Q

Bradykinin (Bk)

A

Non-Neural Hormone Peptide

Vasodilation & Increase Vascular Permeability
Stimulates Pain Nerve Endings
Stimulates Fluid Secretion
Contracts Intestine/Uterus

Binds B1 and B2
G-Protein Coupled Receptors

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7
Q

Kininogen

A

Converted into Bradykinin by protease

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8
Q

Kallikrein

A

Cuts Kininogen and converts it into Bradykinin

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9
Q

Angiotensin-Converting Enzyme (ACE)

A

Inactivates Bradykinin

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10
Q

Growth Factors

A

Small Proteins that bind to Kinase-Linked Receptors

Stimulate Cell Differentiation and Proliferation

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11
Q

Erlotinib

A

Protein Kinase Inhibitor
Inhibits Kinase-Linked Receptors

Preventing Growth Factors from binding
Used to treat cancer and stop tumour growth

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12
Q

Sunitinib

A

Protein Kinase Inhibitor
Inhibits Kinase-Linked Receptors

Preventing Growth Factors from binding
Used to treat cancer and stop tumour growth

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13
Q

TNFa

A

Pro Inflammatory Interleukin

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14
Q

IL-1 alpha/beta

A

Pro Inflammatory Interleukin

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15
Q

IL-4, IL-10, IL-13

A

Anti Inflammatory Interleukin

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16
Q

Adalimumab

A

Monoclonal Antibody against TNFa (Pro Inflammatory Interleukin)

Treats inflammation diseases like:
Rheumatoid Arthritis
Chhorn’s Disease

17
Q

MCP-1

A

Chemokine

18
Q

RANTES

A

Chemokine

19
Q

CXCL-12

A

Chemokine

20
Q

IFN alpha

A

Interferon

Treats chronic hepatitis B & C
Treats malignant disease

21
Q

IFN beta

A

Interferon

Treats relapsing Multiple Sclerosis

22
Q

IFN gamma

A

Interferon

Used in Immunodeficient Diseases to reduce infection
(Chronic Granulomatous Disease)

23
Q

Erythropoietin

A

Colony Stimulating Factor
EPO

Stimulates Red Blood Cell Production

24
Q

Filgrastim

A

Colony Stimulating Factor
Recombinant Granulocyte

Stimulates White Blood Cell Production

PHARM 203 Drugs (1st Midterm) (8 decks)

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