Histamine Flashcards
Antihistamines
Inverse Agonist
Binds to unliganded H1 receptors and keeps them in an inactive state
Cimetidine
Peptic Ulcer Drugs
Binds to H2 receptors
Diphenhydramine
First Generation Antihistamine
Enters CNS –> Sedates
Blocks H1 and Cholinergic/Adrenergic/Serotonergic
Hydroxyzine
First Generation Antihistamine
Enters CNS –> Sedates
Not Specific
Blocks H1 and
Cholinergic/Adrenergic/Serotonergic
Cetirizine
Second/Third Generation Antihistamines
Enter CNS Less
Fewer Autonomic Effects
Less Sedating
Specific for H1
Loratidine
Second/Third Generation Antihistamines
Enter CNS Less
Fewer Autonomic Effects
Less Sedating
Specific for H1
Fexofenadine
Second/Third Generation Antihistamines
Enter CNS Less
Fewer Autonomic Effects
Less Sedating
Specific for H1
Levoceterizine
Second/Third Generation Antihistamines
Enter CNS Less
Fewer Autonomic Effects
Less Sedating
Specific for H1
Desloratadine
Second/Third Generation Antihistamines
Enter CNS Less
Fewer Autonomic Effects
Less Sedating
Specific for H1