Serotonin

Question 1

monoamine

Answer 1

Serotonin

Question 2

90% of the 5-HT in your body is found in the

Answer 2

gut

Question 3

5-HT is a major neurotransmitter in the

Answer 3

enteric nervous system and is released by enterochromaffin cells

Question 4

5-HT stimulates

Answer 4

peristalsis and secretion into the intestines

Question 5

5-HT is massively released in response to

Answer 5

chemical, physical, or pathological stimuli and can activate vagal afferents to signal the brain in generation of nausea & act at the area postrema (chemoreceptor trigger zone)

Question 6

Synthesis of serotonin

Answer 6

L-tryptophan converted to 5-HT by TH

Question 7

breakdown of serotonin

Answer 7

5-HT – MAO –> 5-Haa

Question 8

when eating turkey for example

Answer 8

proteins are created increasing competition of L-tryptophan less tryptophan less serotonin = sleepy

Question 9

Para-chlorophenylalanine (PCPA) is used in animals to rapidly

Answer 9

deplete 5-HT

Question 10

PCPA is an

Answer 10

irreversible inhibitor of tryptophan hydroxylase

Question 11

1-2 doses of PCPA depletes

Answer 11

5-HT by up to 90% for up to 2 weeks

Question 12

Reserpine also depletes

Answer 12

5-HT by inhibiting VMAT

Question 13

Tryptophan can be depleted in humans by administering an

Answer 13

amino acid mix devoid of tryptophan

Question 14

Fenfluramine

Answer 14

Prescribed for weight loss in obese patients

Question 15

Some substituted amphetamines

Answer 15

Para-chloroamphetamine
(MDMA)

Question 16

Dopamine and 5-HT are directly opposed in regulating

Answer 16

appetite

Question 17

Dopamine is released in response to

Answer 17

food stimuli (smell), stimulates appetite

Question 18

5-HT generated as a result of

Answer 18

eating inhibits dopamine release, decreasing appetite

Question 19

Fenfluramine is a

Answer 19

5-HT releaser

Question 20

Phentermine

Answer 20

supresses appetite through effects on catecholamines (psychostimulant similar to amphetamine)

Question 21

5-HT transporters (SERT)

Answer 21

Responsible for inactivation of 5-HT signalling by reuptake

Question 22

drugs that affect DAT, NER, SERT

Answer 22

cocaine and amphetamines, antidepressants)

Question 23

SERT also found in

Answer 23

lungs, placenta, and platelets

Question 24

SERT pumps

Answer 24

systemic 5-HT into platelets

Question 25

SERT Functions in

Answer 25

clotting cascades as a vasoconstrictor

Question 26

TCA antidepressants (non-selective for SERT, NET)

Answer 26

Imipramine

Question 27

SSRI antidepressants (selective for SERT)

Answer 27

Fluoxetine

Question 28

SNRI antidepressants (non-selective for SERT, NET)

Answer 28

Venlafaxine

Question 29

SNDRI antidepressants

Answer 29

(SERT ~ NET > DAT)

Question 30

Psychoactive drugs (non-selective for SERT, NET, DAT)

Answer 30

Cocaine, amphetamines, MDMA