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Neuro-pharmacology > Serotonin > Flashcards

Serotonin Flashcards

1
Q

monoamine

A

Serotonin

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2
Q

90% of the 5-HT in your body is found in the

A

gut

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3
Q

5-HT is a major neurotransmitter in the

A

enteric nervous system and is released by enterochromaffin cells

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4
Q

5-HT stimulates

A

peristalsis and secretion into the intestines

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5
Q

5-HT is massively released in response to

A

chemical, physical, or pathological stimuli and can activate vagal afferents to signal the brain in generation of nausea & act at the area postrema (chemoreceptor trigger zone)

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6
Q

Synthesis of serotonin

A

L-tryptophan converted to 5-HT by TH

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7
Q

breakdown of serotonin

A

5-HT – MAO –> 5-Haa

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8
Q

when eating turkey for example

A

proteins are created increasing competition of L-tryptophan less tryptophan less serotonin = sleepy

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9
Q

Para-chlorophenylalanine (PCPA) is used in animals to rapidly

A

deplete 5-HT

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10
Q

PCPA is an

A

irreversible inhibitor of tryptophan hydroxylase

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11
Q

1-2 doses of PCPA depletes

A

5-HT by up to 90% for up to 2 weeks

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12
Q

Reserpine also depletes

A

5-HT by inhibiting VMAT

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13
Q

Tryptophan can be depleted in humans by administering an

A

amino acid mix devoid of tryptophan

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14
Q

Fenfluramine

A

Prescribed for weight loss in obese patients

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15
Q

Some substituted amphetamines

A

Para-chloroamphetamine
(MDMA)

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16
Q

Dopamine and 5-HT are directly opposed in regulating

A

appetite

17
Q

Dopamine is released in response to

A

food stimuli (smell), stimulates appetite

18
Q

5-HT generated as a result of

A

eating inhibits dopamine release, decreasing appetite

19
Q

Fenfluramine is a

A

5-HT releaser

20
Q

Phentermine

A

supresses appetite through effects on catecholamines (psychostimulant similar to amphetamine)

21
Q

5-HT transporters (SERT)

A

Responsible for inactivation of 5-HT signalling by reuptake

22
Q

drugs that affect DAT, NER, SERT

A

cocaine and amphetamines, antidepressants)

23
Q

SERT also found in

A

lungs, placenta, and platelets

24
Q

SERT pumps

A

systemic 5-HT into platelets

25
Q

SERT Functions in

A

clotting cascades as a vasoconstrictor

26
Q

TCA antidepressants (non-selective for SERT, NET)

A

Imipramine

27
Q

SSRI antidepressants (selective for SERT)

A

Fluoxetine

28
Q

SNRI antidepressants (non-selective for SERT, NET)

A

Venlafaxine

29
Q

SNDRI antidepressants

A

(SERT ~ NET > DAT)

30
Q

Psychoactive drugs (non-selective for SERT, NET, DAT)

A

Cocaine, amphetamines, MDMA

Neuro-pharmacology (26 decks)

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