Serotonin

Question 1

Which five HT antagonist increases appetite and it’s useful in carcinoid and post gastrectomy dumping syndrome

Answer 1

Cyproheptadine

Question 2

Name a 5 HT2A Antagonist in alpha-1 blocker that has antihypertensive effect

Answer 2

Ketanserin

Question 3

Which 5HT3 receptor antagonist are used as an anti-emetics

Answer 3

1. Ondansetron
2. granisetron

Question 4

What are the uses of serotonin antagonist

Answer 4

1. Migraine
2. sedation
3. anticholinergic
4. anti-hypertensive
5. anti-emetic
6. used in schizophrenia
7. postpartum haemorrhage
8. parkinsonism
9. galactorrhea

Question 5

Which drugs can be used to treat acute attacks of migraine

Answer 5

1. Nonsteroidal anti-inflammatory drugs (NSAIDs) - paracetamol, Aspirin, ibuprofen, diclofenac
2. Anti-emetics - Metoclopramide, domperidone, prochlorperazine, promethazine
3. Ergot preparation - ergotamide, Dihydroergotamine
4. Triptans

Question 6

What is the mechanism of action of Ergotamide

Answer 6

Partial agonist 5HT1B/1D receptors in Cranial blood vessels. Construction of dilated blood vessels and decreases inflammatory and extravasation of plasma in to perivascular space.

Question 7

What chemical increases ergotamide absorption

Answer 7

Caffeine

Question 8

What is the mechanism of action of triptan

Answer 8

Selective 5HT1B/1D agonist. Construct dilated cranial blood vessels and arterial venous shunt. Inhibit extravasation of plasma proteins in the perivascular space.
Inhibit the release of inflammatory peptides from nerve ending in the perivascular space to decrease inflammation

Question 9

Name triptans

Answer 9

1. Sumatriptan
2. RizaTripton
3. Eletriptan
4. Naratriptan
5. FrovaTriptan

Question 10

What are the adverse effects of Triptans

Answer 10

1. Paraesthesia
2. tightness in the chest
3. flushing, dizziness, nausea
4. pain at the side of injection
5. rise in BP and coronary vasospasm

Question 11

What are the contraindications of Triptans

Answer 11

1. Pregnancy
2. patients with ischaemic heart disease
3. peripheral vascular disease
4. hypertension
5. in patients with risk factor for coronary artery disease

Question 12

Which drugs are used for the prophylaxis of migraine

Answer 12

ABCD
1.  Anticonvulsants
2. Beta blockers
3. calcium channel blockers
4. Antidepressants (tricyclic)
5. Other - methysergide and cyprohepatadine