NSAIDs Flashcards
Classify an NSAIDs
- Nonselective COX inhibitors
a) salicylates
b) propanoic acid derivatives
c) fenamic acid derivatives
d) acetic acid derivatives
e) enolic acid derivatives - Preferential COX2 inhibitors
- highly selective COX2 inhibitors
- analgesic and antipyretics with poor anti-inflammatory effect
Name nonselective COX inhibitors that are salicylates
- Aspirin
- diflunisal
Name nonselective COX inhibitors that are propanoic acid derivatives
- Ibuprofen
- naproxen
- ketoprofen
- Flurbiprofen
Name fenamic Acid derivatives of nonselective COX inhibitors
- Mefenamic acid
- Flufenamic
Name nonselective COX inhibitors that are ascetic acid derivatives
- Ketorolac
- Indomethacin
Name nonselective COX inhibitors that are in enolic acid derivatives
- Piroxicam
- Tenoxicam
- Lornoxicam
Name preferential COX2 inhibitors
- Diclofenac
- meloxicam
- Aceclofenac
- Nimesulide
Name highly selective COX2 inhibitors
- Etroicoxib
- Patecoxib
- Lumiracoxib

Name analgesic and antipyretic with poor anti-inflammatory effect
- Paracetamol
- Nefopam 
What is the mechanism of action of NSAIDs
Inhibit both COX1 and COX2 Isoforms. Thereby decreasing PGs and thromboxane synthesis.
All NSAIDs Cause reversible inhibition of COX enzyme except for which drug
Aspirin
Name the pharmacological action of NSAIDs
- Analgesic effect
- Anti-pyretic effect by inhibition of PGs in hypothonimus
- anti-inflammatory effect by inhibition of PG synthesis
- antiplatelet effect: inhibits TXA2 synthesis
- Acid base electrolyte balance
- GIT produces vomiting and Irritates gastric mucosa
- CVS: sodium and water retention can cause CCF and hyper tension
- urate excretion

What is the dosage of regimen of aspirin for analgesic dose
2 to 3 g /day in divided doses
What is the dosage regimen of anti-inflammatory dose of aspirin
4 to 6 g /day in divided doses
What is the dosage regimen for aspirin for antiplatelet dose
50 to 325 mg/day