Prostaglandins

Question 1

What are the uses and pharmacological action of prostaglandins

Answer 1

1. GI tract: reduces gastric acid secretion and increases the creation of mucus and prevents NSAID induced ulcers
2. CVS: maintains the patency of ductus arteriosus before surgery. decreases peripheral, pulmonary and coronary resistance. Used to treat hypertension. Pulmonary hypertension
3. Platelets: inhibits platelet aggregation
4. Eye: decrease intraocular tension. Used in glaucoma
5. Uterus: contract pregnant uterus, abortion, induction of labor, cervical priming, postpartum haemorrhage
6. Male reproductive system: useful in treatment of erectile disfunction

Question 2

Which drugs are used in glaucoma

Answer 2

1. LatanoProst
2. Bimatoprost
3. Unoprostone
4. Travoprost

Question 3

Which drug is used to maintain the patency ductus arteriosus in neonates with congenital heart disease and erectile disfunction

Answer 3

Alprostadil

Question 4

Which drugs can be used in peptic ulcers

Answer 4

Misoprostol 

Question 5

Which drugs can be used for pulmonary hypertension

Answer 5

1. Epoprostenol
2. Treprostinil
3. Iloprost

Question 6

What are the therapeutic uses of prostaglandins in obstetrics

Answer 6

1. Abortion
2. induction of labour
3. postpartum haemorrhage

Question 7

Which drugs are used in abortion

Answer 7

1. Dinoprosterone: Third trimester abortion
2. Misoprostol: Abortion in early pregnancy
3. carboprost: abortion in second trimester
4. Gemeprost and DinoProst

Question 8

What drugs are used in postpartum haemorrhage

Answer 8

1. Carboprost
2. misoprost

Question 9

What are the adverse effects of using prostaglandins

Answer 9

1. Nausea, vomiting, diarrhea, fever
2. Flushing
3. hypotension
4. backache