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neuropharm > SEROTONIN > Flashcards

SEROTONIN Flashcards

1
Q

5-HT synthesized from

A

tryptophan

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2
Q

tryptophan catalyzed by

A

TPH to 5 HTP, catalyzed by AADC to 5-HT

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3
Q

PCPA

A

blocks 5-ht synthesis by inhibiting TPH

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4
Q

kynurenine

A

ingested tryptophan metabolized to

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5
Q

SSRIs

A

inactivation of 5-HT, reuptake by 5-HT transporter

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6
Q

VMAT2

A

blocked by resperine, depletes 5-HT

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7
Q

5HT1A receptor

A

inhibit adenylyl cyclase to decrease cAMP synthesis, membrane hyper polarization

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8
Q

5HT2A receptor

A

increases Ca and PKC

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9
Q

5HT1A receptor medicine

A

anxiety regulating, postsynaptic

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