GLUTAMATE

Question 1

glutamate is excitatory or inhibitory

Answer 1

excitatory

Question 2

glutamate is ionized form of

Answer 2

glutamic acid

Question 3

glutamate is formed by

Answer 3

glutamine by glutaminase

Question 4

VGLUT

Answer 4

vesicular glutamate transporters

Question 5

glutamate uptake

Answer 5

astrocytes with excitatory amino acid transporters

Question 6

glutamine synthetase

Answer 6

converts glutamate to glutamine

Question 7

glutaminase

Answer 7

converts glutamine to glutamate

Question 8

glutamate functions

Answer 8

synaptic plasticity, learning and memory, psychopathologic disorders

Question 9

glutamate ionotropic receptors

Answer 9

AMPA, kainate, NMDA

Question 10

NMDA

Answer 10

allows Ca and Na to pass through, activates second messenger, binding site for Mg

Question 11

NBQX

Answer 11

antagonist of AMPA and kainate, causes sedation and ataxia

Question 12

NMDA activated

Answer 12

glutamate and co agonist (glycine or D-serine)

Question 13

glutamate metabotropic receptors

Answer 13

mGluR1-mGluR8

Question 14

I-AP4

Answer 14

selective agonist of mGluR4,6-8 auto receptors, suppress transmission

Question 15

AMPA positive allosteric modulators are

Answer 15

cognitive enhancers

Question 16

long term potentiation (LTP)

Answer 16

NMDA, persistent increase in synaptic strength because of burst of energy in pre synaptic neuron

Question 17

excitotoxicity hypothesis

Answer 17

excessive exposure to glutamate causes prolonged depolarization of neurons leading to damage or death