GABA

Question 1

GABA is inhibitory or excitatory

Answer 1

inhibitory

Question 2

GABA synthesized from

Answer 2

glutamate by glutamic acid decarboxylase

Question 3

VGAT

Answer 3

moves GABA to vesicles

Question 4

GABA removed

Answer 4

by GAT-1,2,3

Question 5

Tiagabine

Answer 5

selective inhibitor of GAT-1, treats epilepsy

Question 6

GABA metabolized to

Answer 6

glutamate by GABA-T

Question 7

GABA a receptors

Answer 7

ionotropic, Cl in, hyper polarization and inhibition

Question 8

GABA b receptors

Answer 8

metabotropic

Question 9

benzodiazepines, barbiturates, ethanol

Answer 9

positive allosteric modulators, enhance action of GABA

Question 10

anesthetics

Answer 10

enhance GABA a

Question 11

postsynaptic GABA b receptors

Answer 11

inhibit neuronal firing by stimulating potassium channel opening, inhibit adenylyl cyclase and reduce cAMP formation

Question 12

presynaptic GABA b receptors

Answer 12

inhibitor transmitter release by inhibiting Ca channel opening, inhibit adenylyl cyclase and reduce cAMP formation

Question 13

muscle relaxants

Answer 13

GABA agonists