Ser/Thr Phosphatases

Question 1

phosphates oppose

Answer 1

kinases

Question 2

phosphorylation is important in

Answer 2

cell regulation

Question 3

protein phosphorylation coordinates process within cells to provide

Answer 3

tight control of cell physiology

Question 4

phosphorylation of regulatory proteins defines the

Answer 4

strength and duration of physiological responses

Question 5

are phophataes very divers?

Answer 5

no

Question 6

sites that kinases act on to regulated cellular processes must have a

Answer 6

low basal state of phosphate incorporation

Question 7

phosphatases act

Answer 7

constiutively and maintain constant opposition to kinases

Question 8

4 major classes of phosphatases

Answer 8

1. type-1
2. type -2A
3. cacineurin
4. type 2-C

Question 9

inhibitors for type1 and type 2A

Answer 9

are general inhibitors

Question 10

calcineurin is resistant to

Answer 10

inhibitors for type 1 and 2A

Question 11

main result of toxicity to PP1 and PP2A are

Answer 11

tumor promotion
microtubule instability and neurodegeneration
cell death

Question 12

targets for all inhibitors are the

Answer 12

CATALYTIC SUBUNITS

Question 13

okadaic acid - target organ

Answer 13

small intestine

Question 14

okadaic acid - symptoms

Answer 14

diarrhea, nausea, vomiting, pain , chills

Question 15

okadaic acid - duration

Answer 15

lasts up to 3 days

Question 16

microcystin toxicity

Answer 16

most serious
product of blue-green algae
selective hepatotoxins

Question 17

primary targets of microcystins?

Answer 17

PPas1 & 2A

Question 18

why do PPase inhibitors cause different toxic effects?

Answer 18

distribution is different

Question 19

calcineurin inhibitors does NOT

Answer 19

kill the cells

Question 20

calcineurin is the only major phosphatase to be

Answer 20

positively regulated