Exam 2 Study

Question 1

Fragmentation of proteins can be caused by

Answer 1

oxidation of proteins in the presence of oxygen by ionizing radiation

Question 2

Formation of Nitrotyosin in proteins can be caused by

Answer 2

reaction of proteins with peroxynitrate

Question 3

Intra and Inter molecular cross-links of proteins can be caused by 2 things

Answer 3

1. oxidation of proteins in the absence of oxygen by ionizing radiation
   and/or
2. reaction of proteins with aldehydes such as 4-hydroxynonal

Question 4

molecules involved with hydrogen abstraction on polyunsaturated fatty acids

Answer 4

hydroxyl radical

lipid peroxy radical

Question 5

molecules involved with cooxidation

Answer 5

acetaminophen

peroxidase component of prostaglandin H synthase

Question 6

molecules involved with Reduction of Fe(III) to Fe(II) and Cu(II) to Cu(I)

Answer 6

O2-

ascorbate

Question 7

molecules involved with REDOX cycling

Answer 7

paraquat
Doxorubicin
NADPH CYP450 reductaces

Question 8

transgenic mice overexpressing CYP450 2E1 in liver

Answer 8

less resistant/more susceptible to alcohol induced liver injury

Question 9

KO mice deficient in CYP450 2E1

Answer 9

more resistant/less susceptible to alcohol induced liver injury

Question 10

KO mice deficient in class2 aldehyde dehydrogenase

Answer 10

less resistant/ more susceptible to alcohol induced liver injury

Question 11

KO mice deficient in Cu-Zn superoxide dismutase

Answer 11

less resistant/more susceptible to alochol induced liver injury