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Year 2 Diabetes & Endocrinology (JK) > Self learn immunology of endocrine disorders > Flashcards

Self learn immunology of endocrine disorders Flashcards

1
Q

What are autoimmune diseases a multifactorial interaction of?

A

Genetic factors
environmental factors
immune regulatory factors
hormonal factors

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2
Q

What are the possible pathogenesis of autoimmune diseases?

A 
antibody mediated 
cell mediated 
complement mediated
phagocytes, NK, cytokines
combination
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3
Q

What genes are associated with autoimmune diseases?

A

HLA genes

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4
Q

Associations with autoimmune diseases

A

family
women
monozygotic twins

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5
Q

What are organ specific autoimmune diseases?

A

An organ-specific disease is one in which an immune response is directed toward antigens in a single organ

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6
Q

Give some examples of organ specific autoimmune diseases

A

thyroid eg hashimotos
addisons
pernicious anaemia
Type 1 DM

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7
Q

Give some examples of non organ specific autoimmune diseases

A

SLE
rheumatoid arthritis
also skin and muscle

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8
Q

What are the roles of HLA in autoimmunity? (3)

A

receptors for aetiological agents
molecular mimicry
influence on tolerance induction or positive selection of particular T cell clones

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9
Q

Stimulating antibodies diseases

A

Graves

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10
Q

Blocking ab diseases

A

pernicious anaemia
myxoedema
IDDM

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11
Q

Cell mediated diseases

A

hashimotos

addisons

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12
Q

Primary and secondary roles of autoantibodies

A 
primary = pathological agents
secondary = diagnosis, prognosis and response to therapy
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13
Q

potential known autoantigens in autoimmune thyroid disease

A

TSH receptor
thyroglobulin
peroxidase
other

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14
Q

Autoimmune mechanism of graves disease

A

humoral

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15
Q

Mechanism of hashimotos disease

A

humoral - goitre

cellular - destruction and hypofunction

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16
Q

3 mechanisms of autoimmune thyroid disease

A

antibody mediated
cell mediated
both

17
Q

2 functional effects of autoimmune thyroid disease

A

hypofunction

hyperfunction

18
Q

Hereditary factors in type 1 DM

A

HLA eg B8, DR3

twin

19
Q

Environmental influences of type 1 DM

A

diet/infection
seasonal onset
geographical variation

20
Q

List some glands affected by autoimmune endocrine disease

A 
thyroid 
kidneys 
pancreas 
stomach
others are rare
21
Q

Do autoimmune polyendocrine syndromes affect men or women more?

22
Q

type 1 APS

A

adrenal, parathyroid and candidiasis

23
Q

Type 2 APS

A

thyroid, adrenal, IDDM

24
Q

Type 3 APS

A

thyroid and one of IDDM, gastric or non organ specific eg SLE, RA

Year 2 Diabetes & Endocrinology (JK) (24 decks)

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