Seizures and CP Flashcards
Define febrile seizures
Occur between 6m to 6years with no underlying neurological disease
Define status epilepticus
Ongoing seizures more than 5 minutes or multiple seizures without returning to normal
Define partial seizures and 2 subdivisions
Involve only one hemisphere
Simple - no impaired consciousness
Complex- impaired consciousness
Define generalized seizures
Involve both hemispheres and associated with loss of consciousness
Describe history in epilepsy x10
Classification of seizure
Prodromal symptoms and aura
Initial localizing signs
Description of all manifestations of the seizure
Duration, frequency, time of occurrence in the day
Date and time of last seizure
Predisposing factors and postictal events
Physical exam inspection x3
Dysmorphic features
Diagnostic rashes
Asymmetry - in long standing hemiplegia
Investigations in epilepsy x4
Electroencephalogram to characterize seizure
Biological evaluation of electrolytes
Blood glucose level
Brain imaging
Indication for brain imaging x3
Focal signs- abnormal neurological findings
Developmental delay or regression
Seizure that are difficult to control
Common problems in management of epilepsy x3
Increased frequency and worsening of seizures
Intractable seizures- not responsive to treatment
Seizures changing in nature
Differential diagnosis of epilepsy x3
Syncope ie passing out
Breath holding attacks
Undiagnosed structural lesions eg tumor
State 5 problems that may arise with epilepsy medication
Wrong drug, wrong dose, adverse drug interactions, wrong diagnosis, poor compliance
Management during a seizure x4
Lie the child on the back
Dont put objects in mouth
Move any nearby objects that may be harmful
Have a time plan to seek medical attention
Causes of intercurrent problems affecting management of seizures x2
Intercurrent infection - UTI
Electrolyte imbalance induced by drugs
How to explain treatment to parents x4
Reasons for recommending treatment
Benefits and possible side effects
Probable duration
Why monotherapy is important x2
Some drugs reduce efficacy of others
Some drugs metabolize the other drug
Criteria for stopping seizure treatment x2
Seizure free for 2 to 4 years
Individualized risk benefit assessment
Factors affecting increased probability of seizure recurrence after stopping treatment x3
Abnormal neurological signs
Mixed type seizure
Focal seizures/ seizures originally difficult to treat
Anticonvulsants for generalized tonic clonic seizures x4
Carbamazepine
Phenobarbitone
Valproate
Phenytoin
Anticonvulsants for absent seizures x3
Ethosuximide
Valproate
Clonazepam
Anticonvulsants for simple and complex partial seizures x3
Carbamazepine
Valproate
Phenytoin
Describe infantile seizures and their treatment
They look like a startle- stiff arms and legs with head bent forwards
Prednisolone
Side effects of anticonvulsants x5
Acute toxicities eg nystagmus and ataxia
Chronic toxicities- teratogenicity, hematological effects
Acute idiosyncratic (abnormal physical reaction) reactions eg stevens johnson syndrome
Drug interactions between anticonvulsants
Drug interactions with other drugs
Risk factors of febrile seizure x2
Age 6-60months
Temperature greater or equal to 38 degrees
Characteristics of febrile seizures x4
Generalized
Usually tonic clonic
Lasting for maximum of 15 minutes
Non recurrent within a period of 24 hours