Segars - Pharm of IBD, UBS, & CIC

Question 1

TNF-alpha inhibitors used for both UC and CD

Answer 1

• adalimumab

- infliximab

Question 2

TNF-alpha inhibitors used only for CD

Answer 2

certolizumab

Question 3

TNF-alpha inhibitors used only UC

Answer 3

golimumab

Question 4

alpha-4 integrin inhibitor used for UC

Answer 4

vedolizumab

Question 5

alpha-4 integrin inhibitors used for CD

Answer 5

• natalizumab

- vedolizumab

Question 6

5-ASA agents

Answer 6

• sulfsalazine
• masalamine
• olsalazine
• balsalazine

Question 7

5-ASA drug formulated w/ inert carrier

Answer 7

balsalazide

Question 8

5-ASA made with 2 molecules of 5-ASA

Answer 8

olsalazine

Question 9

AEs: TNF-alpha inhibitors

Answer 9

• infection!*
• GI: N/V/D
• HA/arthralgias/fatigue
• liver > inc LFTs

Question 10

SAE: alpha-4 integrin inhibitors

Answer 10

PML

Question 11

SAE: alosteron

Answer 11

ischemic colitis

Question 12

CI: GI stimulants

Answer 12

• gi obst
• ileus
• impaction

Question 13

precolonoscopy prep

Answer 13

• prepopik
• large doses of PRG-3350
• bisacodyl

Question 14

osmotic agent also used in sever liver disease

Answer 14

lactulose

Question 15

osmotic agent used in bowel prep prior ti GI scopes and procedures

Answer 15

polyethylene glycol