Fitz - Pharm of Infectious Helmeniths & Protazoa Flashcards
1
Q
benzimidazoles
A
- slbendazole
- mebendazole
2
Q
MOA: benzimidazole
A
bind to parasite beta-tubulin > disrupt microtubule polymerization & microtubule dependent processes
3
Q
tx: mebendazole
A
- enterobius vermicularis (pinworm)
- ascaris lumbricoides
- tricuris tricuria (whipworm)
4
Q
tx: albendazole
A
- necator americanus + ancylosomia duodenale (hook worms)
- ascaris lumbricoides
- tricuris tricuria (whipworm)
- toxocara spp
- larval migrans (hook worm)
- larval forms of tapeworm
5
Q
metabolite of albendazole w/ goo systemic exposure
A
albendazole sulfoxide
6
Q
MOA: pyrantel
A
depolarizing neuromuscular blocking agent > persistent activation of nAChRs > spastic paralysis of the worm
7
Q
tx: ivermectin
A
- onchocerciasis (river blindness)
- lymphatic filiarisis
- wucheria bancrofti
- bugia malayi
8
Q
tx: praziquantel
A
- schistosomiasis (liver fluke)
- tape worm in adults
9
Q
component of pathogen that activates metronidazole
A
pyruvate-ferredoxin oxido reductase (PFOR)
10
Q
drug of choice for amebiasis
A
metronidazole
11
Q
hook worm
A
albendazole
12
Q
cytersercosis
A
albendazole
13
Q
schistomiasis
A
praziquantel
14
Q
giardia
A
tinidazole
15
Q
intestinal stronglodies
A
ivermectin
16
Q
riverblindness
A
ivermectin
