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GI II > Seegars - Drugs for Nausea & Vomiting > Flashcards

Seegars - Drugs for Nausea & Vomiting Flashcards

1
Q

drug endings of serotonin receptor agonists

A

-setron

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2
Q

drug endings of neurokinin receptor agonists

A

-pitant

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3
Q

only 5-HT receptor agonist that is not an antiemetic

A

alosetron

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4
Q

most worrisome AE of 5-HT receptor agonists

A

QT prolongation & torsades

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5
Q

5-HT RA with longest T1/2

A

Palonsetron (40h)

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6
Q

only NK1 RA that can be given IV

A

fosaprepitant

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7
Q

NK1 RAs are used with what other drugs for CINV

A
  • glucocorticosteroids

- 5-HT RAs

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8
Q

therapeudic uses of NK1 RAs

A
  • CINV

- prophylaxis for PONV (3 hrs prior to induction)

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9
Q

H1 RAs

A
  • diphenhyramine
  • dimenhydrinate
  • hydroxyzine
  • promethazine
  • meclizine
  • cyclizine
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10
Q

AEs of blocking H1 receptors

A

varying levels of anticholinergic properties

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11
Q

only indication for meclizine & cyclizine

A

motion sickness/vertigo

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12
Q

promethazine black box warnings

A

-resp distress in kid

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13
Q

D2 RAs

A
  • chlorpromazine
  • perphenazine
  • prochlorperazine
  • haloperidol
  • trimethobenzamine
  • metoclopramide
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14
Q

D2 RA that is off-lable/2nd line tx for CINV

A

haloperidol

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15
Q

D2 RA that enhances GI motility and increases LES tone

A

metoclopramide

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16
Q

AEs of D2 RAs

A
  • classic anticholingergic effects

- extrapyramidal side effects (dyskinesias)

17
Q

drug interactions of D2 RAs

A
  • other drugs with anticholinergic effects
  • antiarrhythmics
  • antiHTNs
18
Q

muscarinic (M1) receptor antagonists

A

scopolamine

19
Q

unique mode of delivery of scopolamine

A

patch > worn for 72 h

20
Q

drug used for motion sickness

A

scopolamine

21
Q

AEs of M1 RAs

A

classic anticholinergic effects

22
Q

cannabinoid receptor agonists

A
  • droabinol

- nabilone

23
Q

cannabinoid RAs are reserved for tx of what?

A

CINV that doesn’t respond to other drugs (its a scheduled drug!)

24
Q

MOA: cannabinoid RAs

A

-stim central (CB1) and peripheral (CB2) cannabinoid receptors in VC/CTZ

25
Q

pharmicokinetics of cannabinoid RAs

A
  • short onset time

- long DOA (24h)

26
Q

highly emetogenic 3 drug regimen (ASCO guidelines)

A
  • 5-HT RA
  • NK1 RA
  • corticosteroid (dexamethazone/methyorednisolone)
27
Q

when do you give the 3 drug ASCO guideline therapy?

A
  • prior to chemo

- up to 3-5 days post chemo

28
Q

moderately emetogenic 2 drug regimen (ASCO guidelines)

A
  • 5-HT receptor antagonist

- corticosteroid

29
Q

mild emetogenic 1 drug regimen (ASCO guidelines)

A

corticosteroid

30
Q

3 MC drugs given for PINV

A
  • any 5-HT RA
  • metoclopramide
  • diphenhydramine

GI II (12 decks)

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