Ch 19 - Pancreas Flashcards
1
Q
MC congenital anomaly of pancreas
A
pancreas divisium
2
Q
germline PDX1 mutations
A
pancreatic agenesis
3
Q
risk factors of acute pancreatiis
A
- etoh
- stones
4
Q
grey-turners sign and cullen’s sign
A
acute pancratitis
5
Q
bouts of repeat acute pancreatitis can lead to
A
DM
6
Q
- MC type of pancreatic cyst
- no epi lining
A
pseudocyst
7
Q
- MC in F
- common in tail of pancreas
- p53 and RNF43 gene inactivation
A
serous cystic neoplasm of pancreas
8
Q
- MC in M
- located in larger ducts
- larger cysts
- mucin secretic epi
A
mucinous cystic neoplasm of pancreas
9
Q
- young F
- mainly in tail of panc
- ass’d with wnt signaling
- mutations in CTNNB1
- can be painful
A
solid-pseudopapillary neoplasm
10
Q
- MC in M
- head of pancreas
- benign to malignant spectum
A
IPMNs
11
Q
- 12p
- activating point mutations
- augmentation of cell growth and survival
A
KRAS
12
Q
- 9p
- inactivated tumor suppressor gene in 95% of panc tumors
- famlial clustering with melanoma
A
CDKN2A
13
Q
- 18q
- inactivated tumor suppressor in 55% of ca
A
SMAD4
14
Q
- migratory thrombophelbitis
- grows along nn
- chachexia
A
pancreatic ca
