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Pharmacology 1 > Sedatives/Tranquilizers > Flashcards

Sedatives/Tranquilizers Flashcards

1
Q

What receptors do Acepromazine block?

A

Dopamine, alpha-1, beta-1, histamine

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2
Q

What are the 2 most unwanted side effects of Acepromazine?

A

Vasodilation and hypotension bradycardia (reflex tachycardia), muscle relaxation, lowers seizure threshold

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3
Q

What are the contraindications of Acepromazine?

A

Cardiac disease, seizures (lowers threshold), liver disease

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4
Q

Special considerations for Acepromazine

A

Boxers are more sensitive metabolized in liver drug interactions (opioids further decrease respiration) low bioavailability

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5
Q

Clinical uses of Acepromazine

A

Pre-anesthetic tranquilizer sedation IV, IM, SQ, PO (F=20)

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6
Q

Clinical uses of Prochlorperazine and Promethazine

A

Anti-emetic

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7
Q

What subclass do Acepromazine, Prochlorperazine, and Promethazine belong to?

A

Phenothiazines

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8
Q

What subclass do Azaperone, Droperidol, and Haloperidol belong to?

A

Buterophenones

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9
Q

What receptors do Azaperone block?

A

Dopamine

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10
Q

Clinical uses of Azaperone

A

Decrease aggression in pigs tranquilizer declinine in vet med

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11
Q

Clinical uses of Haloperidol

A

Stop feather plucking

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12
Q

What subclass do Diazepam (Valium), Lorazepam (Ativan), Midazolam (Versed), Alprazolam (Xanax), and Zolazepam belong to?

A

Benzodiazepines

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13
Q

What receptors do Benzodiazepines work at?

A

GABA agonist

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14
Q

Clinical uses for Benzodiazepines

A

Antianxiety anticonvulsant (Diazepam) PO, IM, IV

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15
Q

Side effects of Benzodiazepines

A

Paradoxical excitement (horses and cats)

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16
Q

Contraindications of Benzodiazepines

A

Pregnant animals (teratogen) liver disease (hepatotoxicity) in cats kidney disease

17
Q

Special considerations of Benzodiazepines

A

Metabolized in liver to active metabolites good in very young, very old, and very sick reversed by Flumenazil

Pharmacology 1 (8 decks)

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