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Pharmacology 1 > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

What enzymes do NSAIDs target?

A

Inhibits COX-1 and 2

If it doesn’t inhibit COX, it’s not an NSAID

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2
Q

Which NSAIDs are COX-1 selective inhibitors?

A

Acetylsalicyclic acid

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3
Q

Which NSAIDs are COX-2 preferential inhibitors?

A

Deracoxib
Carprofen
Meloxicam

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4
Q

Which NSAIDs are COX-2 selective inhibitors?

A

Firocoxib

Robenacoxib

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5
Q

Which NSAIDs are non-specific COX inhibitors?

A

Flunixin
Ketoprofen
Phenylbutazone
Fever reducers

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6
Q

T/F: Phenylbutazone and Flunixin bind to feed

A

True

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7
Q

What affect does inflamed tissue have on the distribution of NSAIDs?

A

Inflamed tissue will have a basic environment and will trap acidic drugs

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8
Q

T/F: NSAIDs are not highly protein bound

A

False:

They are highly bound -> low Vd, plasma protein extravasation, drug displacement

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9
Q

T/F: NSAIDs penetrate the CNS and milk

A

False:

They penetrate the CNS but not the milk (dairy cattle have 0 withdrawal time)

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10
Q

Which NSAIDs have active metabolites and what are they?

A

Acetylsalicylic acid = salicylic acid

Phenylbutazone = oxyphenbutazone

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11
Q

Precautions for all NSAIDS

A

Mild renal disease, hepatic disease, hypoproteinemia, late pregnancy, GIT ulcers, and dehydration

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12
Q

Which NSAIDs are best for treating inflammation?

A 
Non-specific COX and preferential COX-2 (not Deracoxib)
Phenylbutazone
Flunixin
Ketoprofen
Carprofen
Meloxicam
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13
Q

Which NSAIDs are best for analgesia?

A

Carprofen

Meloxicam

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14
Q

Which NSAIDs are best for pre-op?

A

Deracoxib

Firocoxib

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15
Q

Which NSAID is the best antithrombotic?

A

Flunixin

Acetylsalicylic acid

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16
Q

Which NSAIDs are commonly used in treating cancer?

A

Piroxicam

Coxibs

17
Q

What condition is most commonly treated with NSAIDs?

A

Osteoarthritis

18
Q

T/F: Acetylsalicylic acid increases clotting time

A

True

19
Q

Which NSAID causes methemoglobinemia?

A

Acetaminophen

20
Q

Which NSAID causes Agranulocytosis?

A

Phenylbutazone

21
Q

T/F: Glucocorticoid therapy increases the chance of GIT irritation/ulceration

A

True

It is contraindicated

22
Q

T/F: Warfarin, anesthetics, etc. compete for binding to plasma proteins and you can see drug displacement

A

True

It is contraindicated

23
Q

T/F: Anticoagulant therapy or poisoning will decrease blood clotting time

A

False: It is contraindicated

It increases clotting time

24
Q

T/F: Furosemide will increase renal excretion and diuretic effect

A

False: It is contraindicated

It decreases renal excretion and diuretic effect

25
Q

Which species is Phenylbutazone most commonly used with?

A

Horses - pain reliever

26
Q

What is the normal function of COX-1?

A

GI secretions
Mucus secretions
Prostaglandins

27
Q

What is the normal function of COX-2?

A

Inflammation

Prostaglandins

Pharmacology 1 (8 decks)

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