NSAIDs Flashcards
What enzymes do NSAIDs target?
Inhibits COX-1 and 2
If it doesn’t inhibit COX, it’s not an NSAID
Which NSAIDs are COX-1 selective inhibitors?
Acetylsalicyclic acid
Which NSAIDs are COX-2 preferential inhibitors?
Deracoxib
Carprofen
Meloxicam
Which NSAIDs are COX-2 selective inhibitors?
Firocoxib
Robenacoxib
Which NSAIDs are non-specific COX inhibitors?
Flunixin
Ketoprofen
Phenylbutazone
Fever reducers
T/F: Phenylbutazone and Flunixin bind to feed
True
What affect does inflamed tissue have on the distribution of NSAIDs?
Inflamed tissue will have a basic environment and will trap acidic drugs
T/F: NSAIDs are not highly protein bound
False:
They are highly bound -> low Vd, plasma protein extravasation, drug displacement
T/F: NSAIDs penetrate the CNS and milk
False:
They penetrate the CNS but not the milk (dairy cattle have 0 withdrawal time)
Which NSAIDs have active metabolites and what are they?
Acetylsalicylic acid = salicylic acid
Phenylbutazone = oxyphenbutazone
Precautions for all NSAIDS
Mild renal disease, hepatic disease, hypoproteinemia, late pregnancy, GIT ulcers, and dehydration
Which NSAIDs are best for treating inflammation?
Non-specific COX and preferential COX-2 (not Deracoxib) Phenylbutazone Flunixin Ketoprofen Carprofen Meloxicam
Which NSAIDs are best for analgesia?
Carprofen
Meloxicam
Which NSAIDs are best for pre-op?
Deracoxib
Firocoxib
Which NSAID is the best antithrombotic?
Flunixin
Acetylsalicylic acid
Which NSAIDs are commonly used in treating cancer?
Piroxicam
Coxibs
What condition is most commonly treated with NSAIDs?
Osteoarthritis
T/F: Acetylsalicylic acid increases clotting time
True
Which NSAID causes methemoglobinemia?
Acetaminophen
Which NSAID causes Agranulocytosis?
Phenylbutazone
T/F: Glucocorticoid therapy increases the chance of GIT irritation/ulceration
True
It is contraindicated
T/F: Warfarin, anesthetics, etc. compete for binding to plasma proteins and you can see drug displacement
True
It is contraindicated
T/F: Anticoagulant therapy or poisoning will decrease blood clotting time
False: It is contraindicated
It increases clotting time
T/F: Furosemide will increase renal excretion and diuretic effect
False: It is contraindicated
It decreases renal excretion and diuretic effect
Which species is Phenylbutazone most commonly used with?
Horses - pain reliever
What is the normal function of COX-1?
GI secretions
Mucus secretions
Prostaglandins
What is the normal function of COX-2?
Inflammation
Prostaglandins
