Sedative Hypnotics: Module 3-Section 01

Question 1

What are sedative hypnotics

Answer 1

CNS Depressants

Question 2

What are the mechanisms of sedative hypnotics

Answer 2

Inhibitory signals from GABA neurons increase the most sedative hypnotics, resulting in decreased glutamate nerve firing.

Question 3

What are benzodiazepines

Answer 3

Most widely prescribed drug in the world.

Question 4

What are benzodiazepines route of administration

Answer 4

Usually taken as a capsule or tablet, but some are available for intravenous or intranasal use

Question 5

What are benzodiazepines mechanisms of action

Answer 5

Activation of the benzodiazepines receptor increases the frequency of 5r opening of the chloride channel

Question 6

What are the therapeutic affects of benzodiazepines

Answer 6

Relaxation, calmness, and relief from anxiety or tension.

Question 7

What is the antidote for benzodiazepines

Answer 7

Flumazenil, a benzodiazepine receptor antagonist that blocks the effects of benzodiazepines

Question 8

Short term adverse efffecrs of benzodiazepines

Answer 8

Drowsiness, lethargy, fatigue, impairment of thinking and memory.

Respiratory depression

Impair motor coordination

Question 9

Long term adverse effects of benzodiazepines

Answer 9

Chronic sedative hypnotics intoxication, such as impaired thinking, poor memory and judgement, disorientation, in coordination, amd slurred speech.

Question 10

Effects of benzodiazepines in pregnant people

Answer 10

Cross the placenta and distribute to the fetus.

Secreted into the milk, exposing nursing infants to therapeutic or toxic doses of the drug.

Question 11

Effects of benzodiazepines in older adults

Answer 11

Can produce cognitive dysfunction in adults. Metabolized more slowly in older adults often leading to over-sedation.