Drug Toxicity And Drug Interactions: Module 1-Section 05 Flashcards
1
Q
What is an extension of a therapeutic affect?
A
Too much of the drug in the blood. Drug Overdose.
2
Q
What is a Therapeutic Index (TI)?
A
Tells you how safe the drug is. Relates the dose of the drug required to produce a beneficial effect to the dose required to produce an adverse effect. The higher the safer.
3
Q
What is the TD50?
A
The dose of drug that is toxic in 50% of the population.
4
Q
How do you calculate the TI?
A
TD50/ED50
5
Q
What is a drug allergy?
A
Antigen-Antibody combination provokes an adverse reaction in the patient.
6
Q
What is teratogenesis?
A
Drug produces defects in a developing fetus.
7
Q
What is an adverse biotransformation reaction?
A
A drug is converted into a chemically reactive metabolite that can bind to tissue components and cause tissue or organ damage.
