Sedation Drugs Flashcards
Propofol
General Anesthetic
MOA- The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors.
Propofol slows the activity of your brain and nervous system. Propofol is used to put you to sleep and keep you asleep during general anesthesia for surgery or other medical procedures. It is used in adults as well as children 2 months and older.
Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
SE- mild itching or rash;
fast or slow heart rate; or
slight burning or stinging around the IV needle.
Midazolam (benzodiazepine)
MOA- The mechanism of action of midazolam indirect and is related to GABA accumulation and its affinity to the benzodiazepine receptors. Two separate receptors for GABA and benzodiazepine couple to a common chloride channel. It increases the frequency of chloride channel opening
SE- amnesia or forgetfulness after your procedure;
drowsiness, dizziness;
nausea, vomiting; or
blurred vision.
