section 7 Flashcards
parameters and conditions associated with microcytosis
Hgb produciton problem
less than 7 um
parameters and conditions associated with macrocytosis
- dna synthesis problem
- greater than 7 um
- megaloblastic changes
which rbc inclusions are viewed on supravital stain
heinz bodies and retics/baso stippiling
cause of ovalo/ellipitocytes
hereditatry horizontal spectrin issue
cause of target cells
increased membrane lipids causeing incrased SA and decreased hgb
cause of sickle cells
abnormal hgbS in low oxygen environment forms stiff bundles
cause of crystal cells
either issues with hgb c snails pr hgb sc birds
cause of envelope cells
clear area on one side of condensed hgb from hgb c issues
cause of burr cells
change in tonicity of intravascular fluid
cause of acanthocytes
abnormal membrane lipids
cause of shistocytes
inclusion removal leaves fragmented RBCs
cause of tear cells
either from inclusion removal or extramedullary hematopoiesis
cause of spherocytes
either from defect/loss of cell membran OR hereditary vertical spectrn issue
cause of stomatocytes
hereditary failure of sodium potassium pumps increasing water in cell OR Rh deficiency
cause of agglutination
due to rbc antibody causing cells to clump
cause of rouleaux
increased Igs blocking zeta potential and lining cells up (removed with saline replacment)
cause of howell-jolly bodies
remnant nuclease from busy BM
cause of basophilic stippling
precipitated RNA in young RBCs (another form of retics)
course stippling from lead poisoning
cause of pappenheimer bodies
granules of iron from ineffective utilization or excess
use of prussian blue stain to confirm
cause of cabot rings
remnant nuclear membrane
cause of heinz bodies
precipitated hgb from ox injury - failure of G6PD and hexose monophosphate pathway
describe hgb H inclusions on supravital stain
looks like golf ball, evenly distributed dots (heinz are irregular)
