Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Section 2 - Quiz Questions > Flashcards

Section 2 - Quiz Questions Flashcards

1
Q

**Match the correct eicosanoid derivative with the statement **

Increases gastric mucosal cytoprotection

A

Match the correct eicosanoid derivative with the statement

Increases gastric mucosal cytoprotection

Misoprostil (PGE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Match the correct eicosanoid derivative with the statement

Stable analogs of this substance are useful in promoting myometrial contractions and expelling pus in open-cervix pyometra

A

Match the correct eicosanoid derivative with the statement

Stable analogs of this substance are useful in promoting myometrial contractions and expelling pus in open-cervix pyometra

_Cloprostenol (PGF2a) _

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Match the correct eicosanoid derivative with the statement

Decreases intraocular pressure in dogs with glaucoma

A

Match the correct eicosanoid derivative with the statement

Decreases intraocular pressure in dogs with glaucoma

_Latanoprost (PGF2a) _

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Aspirin has the lowest potency in:

A

Aspirin has the lowest potency in:

reducing signs of inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which anti inflammatory drug is inactive until it is biotransformed to an active metabolite?

A

Which anti inflammatory drug is inactive until it is biotransformed to an active metabolite?

Cortisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Glucocorticoids increase the number of circulating:

A

Glucocorticoids increase the number of circulating:

Erythrocytes

(GC’s produce pokycythemia, an increase in RBC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which is a sign of corticosteroid excess (Cushingoid syndrome), occurring after long-term therapy with glucocorticoids in dogs?

A

Which is a sign of corticosteroid excess (Cushingoid syndrome), occurring after long-term therapy with glucocorticoids in dogs?

Excessive drinking & urination

(PU/PD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which type of histamine receptor is coupled through G proteins to an increase in intracellular cyclic AMP?

A

Which type of histamine receptor is coupled through G proteins to an increase in intracellular cyclic AMP?

H2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which NSAID inhibits leukotriene synthesis?

A

Which NSAID inhibits leukotriene synthesis?

Tepoxalin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The excretion of aspirin can be increased by _______ the urine

A

The excretion of aspirin can be increased by _______ the urine

Alkalinizing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

**The fever reducing effect of NSAIDs is due to their ability to: **

A

**The fever reducing effect of NSAIDs is due to their ability to: **

Increase body heat loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

**Cyclosporine increases tear formation in inflamed eyes by: **

A

**Cyclosporine increases tear formation in inflamed eyes by: **

Decreasing T cell-mediated ocular immune reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Histamine can be released from mast cells through a receptor-independent mechanism. Some drugs can evoke histamine secretion by this mechniasm because they are strong _________.

A

Histamine can be released from mast cells through a receptor-independent mechanism. Some drugs can evoke histamine secretion by this mechniasm because they are strong _________.

Bases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

**Drugs that act as competitive antagonists at H1-histamine receptors can inhibit: **

A

**Drugs that act as competitive antagonists at H1-histamine receptors can inhibit: **

The dermal “wheal and flare” reaction
(Triple Response of Lewis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

**H1-Histamine receptors are more commonly expressed by: **

A

**H1-Histamine receptors are more commonly expressed by: **

Smooth muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which species manifests poorest phase 2 metabolism of NSAIDs, wuch as aspirin?

A

Which species manifests poorest phase 2 metabolism of NSAIDs, wuch as aspirin?

Cat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which NSAID is a more selective inhibitor of cyclooxygenase-2?

A

**Which NSAID is a more selective inhibitor of cyclooxygenase-2?

Deracoxib**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

**________ is a side effect of therapy with cortisone and prednisone. **

A

**________ is a side effect of therapy with cortisone and prednisone. **

Hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

**Characteristic changes in the differential blood count produced by glucocorticoid administration include: **

**(3) **

A

Characteristic changes in the differential blood count produced by glucocorticoid administration include:

  1. Decreased lymphocyte counts
  2. Increased neutrophil count
  3. Decreased eosinophil count
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Is decreased platelet count a aharacteristic change in the differential blood count produced by glucocorticoid administration?

A

Is decreased platelet count a aharacteristic change in the differential blood count produced by glucocorticoid administration?

NO

21
Q

**Glucocorticoids and cyclosporin share an ability to: **

A

**Glucocorticoids and cyclosporin share an ability to: **

Enhance the spread of active infections

22
Q

Indicate the correct region of the glucocorticoid receptor containing the functional domain:

Glucocorticoid (ligand) binding site

A

Indicate the correct region of the glucocorticoid receptor containing the functional domain:

Glucocorticoid (ligand) binding site

_Carboxy (COOH) end of receptor _

23
Q

Indicate the correct region of the glucocorticoid receptor containing the functional domain:

Receptor dimerization and DNA binding domains

A

Indicate the correct region of the glucocorticoid receptor containing the functional domain:

Receptor dimerization and DNA binding domains

_Middle region of receptor _

24
Q

Which effects can be produced by glucocorticoid treatment?

(2)

A

Which effects can be produced by glucocorticoid treatment?

  1. Hyperglycemia
  2. Hypokalemia
25
Q

Does glucocorticoid treatment cause:

Hypervitaminosis D?

Hypercalcemia?

A

Does glucocorticoid treatment cause:

Hypervitaminosis D? NO

Hypercalcemia? NO

26
Q

Which drug needs to be converted to an active form in the liver in order to be effective in suppressing inflammation?

A

Which drug needs to be converted to an active form in the liver in order to be effective in suppressing inflammation?

Prednisone

27
Q

Which is the most potent antiinflammatory drug?

A

Which is the most potent antiinflammatory drug?

Dexamethasone

28
Q

Which is the shortest-acting antiinflammatory drug?

A

Which is the shortest-acting antiinflammatory drug?

Hydrocortisone

29
Q

Which antiinflammatory produces the most sodium retention?

A

Which antiinflammatory produces the most sodium retention?

Hydrocortisone

30
Q

Mechanism of Action:

Hydrocortisone (Cortisol)

A

Mechanism of Action:

Hydrocortisone (Cortisol)

_Suppresses inflammation by activating cytoplasmic glucocorticoid receptors _

31
Q

Mechanism of Action:

Mifepristone (RU486)

A

Mechanism of Action:

Mifepristone (RU486)

_Inhibits antiinflammatory steroid action by preventing the dissocation of heat shock proteins from glucocorticoid receptors _

32
Q

**Mechanism of Action: **

Diphenhydramine (Benadryl)

A

Mechanism of Action:

Diphenhydramine (Benadryl)

_Inhibits allergic reactions by blocking H1-histamine receptors _

33
Q

Mechanism of Action:

Carprofen (Rimadyl)

A

Mechanism of Action:

Carprofen (Rimadyl)

_Suppresses inflammation by inhibiting cyclooxegenase activity _

34
Q

**Aspirin’s effect on the clotting time of blood is due to its ability to temporarily increase the influence of _______ on platelet aggregation. **

A

**Aspirin’s effect on the clotting time of blood is due to its ability to temporarily increase the influence of _______ on platelet aggregation. **

Prostacyclin (PGI2)

35
Q

**If persistently stimulated by an agonist drug, some G protein-coupled receptors (such as a the beta2-adrenergic receptor) will: **

A

**If persistently stimulated by an agonist drug, some G protein-coupled receptors (such as a the beta2-adrenergic receptor) will: **

B-arrestin

36
Q

**In the dog, glucocorticoids can decrease the numbers of circulating: **

A

**In the dog, glucocorticoids can decrease the numbers of circulating: **

T Lymphocytes

37
Q

**Identify the NSAID **

Which drug, commonly used to alleviate lameness in horses, inhibit both COX-1 and COX-2 isoforms in this species?

A

Identify the NSAID

Which drug, commonly used to alleviate lameness in horses, inhibit both COX-1 and COX-2 isoforms in this species?

Phenylbutazone

38
Q

Identify the NSAID

Which NSAID, given by intravenous injection, is currently approved for use in beef and dairy cattle in the U.S.?

A

Identify the NSAID

Which NSAID, given by intravenous injection, is currently approved for use in beef and dairy cattle in the U.S.?

Flunixin

39
Q

Identify the NSAID

Which drug inhibits both prostanoid AND leukotriene biosynthesis?

A

Identify the NSAID

Which drug inhibits both prostanoid AND leukotriene biosynthesis?

Tepoxalin

40
Q

Identify the NSAID

Which drug irreversibly inhibits cyclooxegenase-1?

A

Identify the NSAID

Which drug irreversibly inhibits cyclooxegenase-1?

Aspirin

41
Q

Which glucocorticoid formulation can be injected intravenously?

Prednisolone Acetate

Prednisolone Sodium Succinate

Triamcinolone Acetonide

A

Which glucocorticoid formulation can be injected intravenously?

Prednisolone Acetate

Prednisolone Sodium Succinate

Triamcinolone Acetonide

42
Q

**Cyclosporin and tacrolimus suppress T lymphocyte signaling by: **

A

**Cyclosporin and tacrolimus suppress T lymphocyte signaling by: **

inhibiting calcineurin activity

43
Q

Which effect of histamine can be reduced or prevented by treatment with diphenhydramine (Benadryl)?

A

Which effect of histamine can be reduced or prevented by treatment with diphenhydramine (Benadryl)?

Increased capillary permeability

44
Q

Which type of drug will decrease the EFFICACY of an agonist?

A

Which type of drug will decrease the EFFICACY of an agonist?

Non-competetive Antagonist

45
Q

**The therapeutic index of a drug is defined as: **

A

**The therapeutic index of a drug is defined as: **

The 50% lethal dose divided by the 50% effective dose

46
Q

Which class of antiinflammatory drugs induces the expression of the intracellular protein I-kB, which inhibits nuclear translocation of the cytokine transcriptional factor NF-kB?

A

Which class of antiinflammatory drugs induces the expression of the intracellular protein I-kB, which inhibits nuclear translocation of the cytokine transcriptional factor NF-kB?

Glucocorticoids

47
Q

Which drug is indicated for the IMMEDIATE reduction of the signs associated with allergy-induced anaphylactoid reactions?

A

Which drug is indicated for the IMMEDIATE reduction of the signs associated with allergy-induced anaphylactoid reactions?

Epinephrine

48
Q
A

Pharmacology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions