Histamine

Question 1

Mast cell histamine inhibitor

Answer 1

Cromoglycate

Question 2

Blocks H1 histamine receptors

Answer 2

Diphenhydramine

Question 3

Blocks H2 histamine receptors

Answer 3

Cimetidine

Question 4

Functional antagonist of histamine

Answer 4

Epinephrine

(increases vasoconstriction)

Question 5

True/False

Epinephrine is an antihistamine

Answer 5

false

Question 6

Major Shock Organs

Human

Dog/Rodent

Rabbit

Answer 6

Human - Lungs

Dog/Rodent - Intestine

Rabbit - Heart

(usually the site with greatest mast cell numbers)

Question 7

1st Generation Antihistamines

examples

Do they cause sedation

Answer 7

Diphenhydramine

Chlorpheniramine

Pyrilamine

Meclizine

Hydroxine

Yes, they cause sedation just like Arno’s voice

Question 8

2nd Generation Antihistamines

examples

do they cause sedation

Answer 8

Cetrizine, Loratidine, Fexofenadine

Nope, they don’t cause sedation

Question 9

What 2 situations would you not want to use a H1 histamine antagonist?

Answer 9

Anaphylaxis

Allergic bronchoconstriction

Question 10

Signal transduction mechanism of:

H1 histamine receptors

H2 histamine receptors

Answer 10

H1 - increase free intracellular calcium

H2 - increase cAMP

Question 11

3 components of the Triple Response of Lewis

and

how are all 3 prevented?

Answer 11

Localized red spot (dilation of microvessels)

Flare

Wheal (localized edema due to increased capillary permeability)

Prevented by H1 histamine receptor antagonists

Question 12

H1 histamine antagonist indications

Answer 12

Allergic diseases

Motion sickness

Conditions secondary to exaggerated histamine production and releas

Question 14

Signs of inflammation - what’s the cause?

Redness

Localized edema

Pain

Answer 14

Redness -> Vasodilation

Localized edema -> Capillary Permeability

Pain -> Sensory Nerves

Question 15

Transcriptional factor linked to inflammation

Answer 15

NF-KappaB