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Hematology 2 Lec > SECONDARY HEMOSTASIS > Flashcards

SECONDARY HEMOSTASIS Flashcards

1
Q

SECONDARY HEMOSTASIS Expected product:

A

fibrin clot

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2
Q

-involves blood vessel and extravascular tissues

A

VASOCONSTRICTION

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3
Q

-needs a signal from CNS → muscular/tissue response → constriction of bv

A

VASOCONSTRICTION

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4
Q

-platelet migrates to the site of injury after adhesion

A

VASOCONSTRICTION

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5
Q
  • Shape changes from normal biconvex to an inactivated form
A

PLATELET ACTIVATION

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6
Q

-: known activator for platelet

A

Collagen

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7
Q

-: product of primary hemostasis

A

Platelet plug

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8
Q

-: activator of coagulation

A

Tissue factor

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9
Q

Pathways:

A
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10
Q

clotting in vitro

A

Intrinsic

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11
Q

exposure of blood to negative surface like glass or plastic

A

Intrinsic

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12
Q

FXII is activated

A

Intrinsic

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13
Q

in vivo coagulation

A

Extrinsic

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14
Q

activator: collagen

A

Extrinsic

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15
Q

product: fibrin clot

A

Extrinsic

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16
Q

FVII is activated

A

Extrinsic

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17
Q

activated by either extrinsic or intrinsic

A

Common

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18
Q

FX is activated

A

Common

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19
Q

FII is activated to IIA

A

Thrombin

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20
Q

All cascade happen to generate thrombin

A

Thrombin

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21
Q

Only activator known for fibrinogen

A

Thrombin

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22
Q

Activates fibrinogen to fibrin to fibrin clot

A

Thrombin

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23
Q

not easily activated unless coagulation factor works altogether or cascade occurs

A

Thrombin

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24
Q

enzyme to the reaction of fibrinogen, fibrin, to fibrin clot, marking secondary hemostasis

A

Thrombin

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25
Q

fibrin clot → bv starts to heal → clot retracts, but becomes obstruction to blood flow

A

Thrombin

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26
Q

most important enzyme to be generated

A

Thrombin

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27
Q

last enzyme to activate fibrinogen

A

Thrombin

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28
Q
  • Plasmin is activated, works on the fibrin clot, and dissolves it by destroying fibrin
A

FIBRINOLYSIS

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29
Q
  • Clot is being dissolved
A

FIBRINOLYSIS

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30
Q

plasma proteins (coagulation factors) + TF + Calcium (cofactor; CF IV) → fibrin clot

A

Coagulation

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31
Q

Role of platelet on Coagulation:

A

-surface area

-formation of platelet-fibrin clot

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32
Q

surface area

A

platelet phospholipid or platelet factor 3 (platelet dust)

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33
Q

Fibrin clot → dissolved as BV starts to heal restore normal blood flow

A

Fibrinolysis

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34
Q

bv starts to heal and clot starts retracting

A

Fibrinolysis

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35
Q

: needed to retract clot → retraction of fibrin clot

A

thrombostenin

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36
Q

proteolytic enzyme capable of degrading fibrin, fibrinogen as well as Factor V and VIII

A

plasmin

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37
Q

Plasminogen is activated as

A

plasmin

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38
Q

: activator of plsmin

A

Tissue plasminogen activator

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39
Q

Plasmin is capable of degrading

A

fibrin, fibrinogen, FV, and FVIII

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40
Q

Plasmin cannot degrade [?], a stabilizing factor

A

CFXIII

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41
Q
  • enhancer of fibrinolysis
A

Protein C and Protein S

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42
Q

In the circulation:

A

zymogens/proenzymes

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43
Q

: coagulation protein → thrombin → fibrinogen → clot

A

Activation

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44
Q

Classification of Coagulation Factors

A
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45
Q

are the substance upon which enzymes act

A

Substrates

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46
Q

accelerate the activities of the enzymes that are involved in the cascade.

A

Cofactors

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47
Q

Cofactors ex

A

(TF, V, VIII, HMWK)

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48
Q

FVII needs Calcium (CFIV) to activate FX

A

Cofactors

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49
Q

FX needs to activate FV to FVa

A

Cofactors

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50
Q

: o serine proteases and transaminase

A

Enzymes

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51
Q

activated FXII activates the substrate FXI

A

Enzymes

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52
Q

FI (fibrin) creates a fibrin clot and FXIII secures the clot to make it strong

A

transaminase

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53
Q

: in order acc to its discovery

A

Roman numeral

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54
Q

Designated “a”:

A

activated

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55
Q

Designated “f”:

A

fragmented factor

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56
Q

Fibrinogen

A

I

57
Q

Thrombin substrate

A

I

58
Q

2-4 days

A

I

59
Q

200-400 mg/dl

A

I

60
Q

Prothrombin

A

II

61
Q

• Prethrombim

A

II

62
Q

Serine protease

A

II
VII
IX
X
XI
XII
PK

63
Q

3 - 4 days

A

II

64
Q

10 mg/dl

A

II

65
Q

Tissue factor

A

III

66
Q

• Tissue Thromboplastin

A

III

67
Q

Cofactor

A

III
V
VIII:C
HMWK/HK

68
Q

Lipoprotein found in most of the body tissues

A

III

69
Q

Insoluble

A

III

70
Q

none

A

III

71
Q

Calcium

A

IV

72
Q

Mineral

A

IV

73
Q

lonized state

A

IV

74
Q

8- 10 mg/dl

A

IV

75
Q

Proaccelerin

A

V

76
Q

• Labile factor

A

V

77
Q

• Accelerator globulin

A

V

78
Q

36 hrs

A

V

79
Q

Most unstable

A

V

80
Q

deteriorates rapidly at RT

A

V

81
Q

1 mg/dl

A

V
X
VWF

82
Q

Proconvertin

A

VII

83
Q

• Stable factor

A

VII

84
Q

• Serum Prothrombin Conversion

A

VII

85
Q

• Accelerator

A

VII

86
Q

• Autoprothrombin I

A

VII

87
Q

3-6 hrs

A

VII

88
Q

Disappears rapidly from the blood when production is halted (eg. coumarin)

A

VII

89
Q

0.05 mg/dl

A

VII

90
Q

Antihemophilic factor (AHF)

A

VIII:C

91
Q

• Antihemophilic Globulin (AHG)

A

VIII:C

92
Q

• Antihemophilic Factor A (AHF-A)

A

VIII:C

93
Q

• Platelet cofactor 1

A

VIII:C

94
Q

Bound to WWF

A

VIII:C

95
Q

0.01 mg/dl

A

VIII:C

96
Q

Plasma thromboplastin component (PTC)

A

IX

97
Q

• Christmas factor

A

IX

98
Q

• Antihemophilic Factor B (AHF-B)

A

IX

99
Q

• Platelet cofactor 2

A

IX

100
Q

18 - 24 hrs

A

IX

101
Q

0.3 mg/dl

A

IX

102
Q

Stuart-Prower factor

A

X

103
Q

• Stuart factor; Prower factor

A

X

104
Q

• Autoprothrombin

A

X

105
Q

40 - 60 hrs

A

X

106
Q

May be stored up to 2 mons at 4°C

A

X

107
Q

Plasma thromboplastin antecedent (PTA)

A

XI

108
Q

• Antihemophilic factor C (AHF C)

A

XI

109
Q

40 - 70 hrs

A

XI

110
Q

Circulates in complex with HMWK

A

XI

111
Q

0.5 mg/dl

A

XI

112
Q

Hageman factor

A

XII

113
Q

• Glass factor

A

XII

114
Q

• Contact factor

A

XII

115
Q

50 - 70 hrs

A

XII

116
Q

Heat stable

A

XII

117
Q

can be stored at 4°C for 3 mons

A

XII

118
Q

Fibrin stabilizing factor (FSF)

A

XIII

119
Q

• Laki-Lorand factor

A

XIII

120
Q

• Fibrinase; Fibrinoligase

A

XIII

121
Q

• Plasma Transglutaminase

A

XIII

122
Q

11 - 14 days

A

XIII

123
Q

2 mg/dl

A

XIII

124
Q

• Fletcher factor

A

Prekallikrein (PK)

125
Q

35 hrs

A

Prekallikrein (PK)

126
Q

35-50mcg/ml

A

Prekallikrein (PK)

127
Q

• Fitzgerald factor

A

High Molecular Weight Kininogen (HMWK/HK)

128
Q

Contact activation cofactor

A

High Molecular Weight Kininogen (HMWK/HK)

129
Q

• William factor

A

High Molecular Weight Kininogen (HMWK/HK)

130
Q

Falujeac factor

A

High Molecular Weight Kininogen (HMWK/HK)

131
Q

9 - 10 hrs

A

High Molecular Weight Kininogen (HMWK/HK)

132
Q

5mg/dl

A

High Molecular Weight Kininogen (HMWK/HK)

133
Q

Factor VIII carrier

A

von Willebrand factor

134
Q

Functions in platelet adhesion

A

von Willebrand factor

135
Q

24hrs

A

von Willebrand factor

136
Q

Phospholipids, Phosphatidy/serine, PF3

A

Platelet factor 3

137
Q

Assembly molecule

A

Platelet factor 3

138
Q

Released by platelets

A

Platelet factor 3

Hematology 2 Lec (29 decks)

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