MDS PART 1

Question 1

Results from clonal abnormalities of hematopoietic pluripotential cells

Answer 1

MDS (Myelodysplastic Syndromes)

Question 2

Group of acquired clonal hematologic disorders characterized by progressive CYTOPENIA defective erythroid, myeloid and
megakaryocytic maturation.

Answer 2

MDS (Myelodysplastic Syndromes)

Question 3

• “Pre-Leukemias”

Answer 3

MDS (Myelodysplastic Syndromes)

Question 4

A. Age:______

Question 5

B. Peripheral blood:___________

Question 6

C. Myeloid cell lines: __________

Question 7

D. Clinical course: _______________

Question 8

Morphologic Abnormalities leading to MDS

Answer 8

1) Dyserythropoiesis
2) Dysmyelopoiesis
3) Dysmegakaryopoiesis

Question 9

-Evident when RBC precursors has abnormal nucleus, nuclear fragments, internuclear bridging and ring sideroblast.

Answer 9

1) Dyserythropoiesis

Question 10

-persistence of basophilia in the cytoplasm of WBC

Answer 10

2) Dysmyelopoiesis

Question 11

–changes include giant platelets and abnormal platelet granulation, either hypogranulation or agranulation.

Answer 11

3) Dysmegakaryopoiesis

Question 12

Two types of MDS:

Answer 12

a) Primary MDS
b) Therapy Related MDS:

Question 13

-Environmental exposure

Answer 13

a) Primary MDS

Question 14

-Mutations caused by chemical, radiation, viral infection or smoking

Answer 14

a) Primary MDS

Question 15

-Genetic inheritance of hematologic disorders.

Answer 15

a) Primary MDS

Question 16

• Chemotherapy

Answer 16

b) Therapy Related MDS

Question 17

• Radiotherapy

Answer 17

b) Therapy Related MDS

Question 18

• Administration of Cytokines (G-CSF or GM-CSF)

Answer 18

b) Therapy Related MDS

Question 19

Classification of MDS

Answer 19

FAB CLASSIFICATION

WHO CLASSIFICATION

Question 20

Retains FAB features

Answer 20

WHO CLASSIFICATION

Question 21

Recognizes molecular, cytogenetic, and immunologic characteristics

Answer 21

WHO CLASSIFICATION

Question 22

Removed categories of CMML and RAEB-t and placed them in MDS/MPD and acute leukemia.

Answer 22

WHO CLASSIFICATION

Question 23

Relies on morphology

Answer 23

FAB CLASSIFICATION

Question 24

Does not address therapy-related or hereditary forms

Answer 24

FAB CLASSIFICATION

Question 25

Does not consider childhood MDS

Answer 25

FAB CLASSIFICATION

Question 26

WHO Classification of MDS

Question 27

Other WHO Classification

Answer 27

a) Myelodysplastic Syndrome, unclassifiable
b) Childhood MDS

Question 28

-refers to subtypes of MDS that lacks specific necessary classifications.

Answer 28

a) Myelodysplastic Syndrome, unclassifiable

Question 29

• refractory cytopenia of childhood (WHO)

Answer 29

b) Childhood MDS

Question 30

FAB Classification of MDS (RAEBIT)
5% blast ____
20-30% blast ____
Auer rods: ___________

Question 31

Differential Diagnosis

Question 32

is not sufficient evidence for MDS

Answer 32

Dysplasia

Question 33

1) Vitamin B12 or Folate Deficiency:

Answer 33

Pancytopenia and Dysplasia

Question 34

2) Copper deficiency:

Answer 34

Reversible MDS

Question 35

3) Fanconi anemia and congenital dyserythropoeitc anemia:

Answer 35

Dysplasia

Question 36

4) Parvovirus B19 and chemotherapeutic drugs:

Answer 36

Dysplasia

Question 37

5) HIV:

Answer 37

Dysplasia