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Hematology 2 Lec > MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME INTRO > Flashcards

MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME INTRO Flashcards

1
Q

Myelo:

A

bone marrow

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2
Q

Dysplastic:

A

abnormal cell devt

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3
Q

Proliferative:

A

excess production of cell

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4
Q

Hypercellular maturation in BM → dysplasia and cytopenia of one or more cell line

A

MYELODYSPLASTIC

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5
Q

Hypercellularity → cytosis of one cell line, usually myeloid lineage (WBCs)

A

MYELOPROLIFERATIVE

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6
Q

(uncontrolled proliferation)

A

MYELOPROLIFERATIVE

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7
Q

(effective/normal hematopoiesis but overproliferation of abnormal cells)

A

MYELOPROLIFERATIVE

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8
Q

(ineffective hematopoiesis; prominent feature)

A

MYELODYSPLASTIC

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9
Q

: tissue-producing cell

A

dysplasia

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10
Q

: ↓ circulating cells

A

cytopenia

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11
Q

↓ bm that produces the cell = ↓ blood produced = ↓ circ cells

A

MYELODYSPLASTIC

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12
Q

: ↑ circulating cells

A

cytosis

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13
Q

Hypercellular: production of blood cells (plt, rbc, wbc)

A

MYELODYSPLASTIC

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14
Q

Ex. Pronormoblast doesn’t mature to a normal mature rbc

A

MYELODYSPLASTIC

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15
Q

Cell lines: erythrocytic, megakaryocytic, myelocytic

A

MYELODYSPLASTIC

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16
Q

Predomination of apoptosis

A

MYELODYSPLASTIC

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17
Q

Proliferation outpaces apoptosis

A

MYELOPROLIFERATIVE

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18
Q

Etiology: unknown

A

MYELODYSPLASTIC

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19
Q

Etiology: mutation of gene

A

MYELOPROLIFERATIVE

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20
Q

↓ cell production

A

MYELODYSPLASTIC

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21
Q

↑ cell production

A

MYELOPROLIFERATIVE

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22
Q

Dysplasia - Ineffective hematopoiesis (bm is not produced effectively or dysplastic) = cytopenic

A

MYELODYSPLASTIC

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23
Q

Proliferation - Normal (effective) but excessive hematopoiesis with hypercellularity

A

MYELOPROLIFERATIVE

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24
Q

↑ cell death

A

MYELODYSPLASTIC

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25
Rbc dies before 120 days
MYELODYSPLASTIC
26
Rate of apoptosis is more than the production rate of rbc
MYELODYSPLASTIC
27
↓cell death, ↑proliferation ≠ Homeostasis ; 1:2
MYELOPROLIFERATIVE
28
After 120 days, apoptotic cell increases as bm proliferates
MYELOPROLIFERATIVE
29
Cell proliferates priod to apoptosis = cytosis
MYELOPROLIFERATIVE
30
Precursor diseases prior to anemia (↓rbc) and leukemia (↓wbc)
MYELODYSPLASTIC MYELOPROLIFERATIVE
31
Premalignant disease
MDS
32
Malignant disease
CMPD
33
One or more cell lines are dysplastic
MDS
34
All cell lines are dysplastic
CMPD
35
Bone marrow cellularity is slightly increased
MDS
36
Cellularity is markedly increased
CMPD
37
Peripheral cytopenia of one or more cell lines
MDS
38
Peripheral cytosis of one cell line
CMPD
39
Iron stores are often increased
MDS
40
Iron is normal or decreased
CMPD
41
No bone marrow fibrosis
MDS
42
Marrow fibrosis is a prominent feature
CMPD
43
No megakaryocyte increase in the bone marrow
MDS
44
Often increased numbers of megakaryocyte
CMPD
45
Splenomegaly is not a feature
MDS
46
Splenomegaly is a frequent feature
CMPD
47
a premalignant process (preleukemic)
MDS
48
a malignant disease
CMPD
49
one or more cell lines are dysplastic
MDS
50
all cell lines are malignant
CMPD
51
usually slightly increased
MDS
52
usually markedly increased
CMPD
53
peripheral cytopenia of one or more cell lines
MDS
54
peripheral cytosis of usually one cell line
CMPD
55
dysplasia of one or more cell lines
MDS
56
morphologically usually normal
CMPD
57
Iron stores often increased
MDS
58
Iron stores normal or decreased
CMPD
59
Bone marrow fibrosis usually none
MDS
60
Bone marrow fibrosis is a prominent feature in the course of disease
CMPD
61
Megakaryocyte population usually no increase in the bone marrow
MDS
62
Megakaryocyte population often increased numbers
CMPD
63
Splenomegaly is not a feature
MDS
64
Splenomegaly is not a feature but a frequent feature
CMPD
65
 Occurs before leukemia
MDS
66
 rbc: dysplastic  wbc, plt: normal
MDS
67
 rbc (erythricytosis), wbc (leucocytosis), and plt (megakaryocytosis)
CMPD
68
 incorporated in rbc to make heme
MDS
69
 ↓ rbc = is not used, but increases in the circulation
MDS
70
 Accumulation of iron
MDS
71
 ↑cell production requires more iron
CMPD
72
 Due to absence of cells
MDS
73
 Cells produced inserts themselves in the sinusoids of bm esp in saturated circulation
CMPD
74
infiltration of cells in the bm, including the sinusoids, normal or abnormal cells
Bone marrow fibrosis
75
 no space for circulation : very infiltrated
MDS
76
Enlargement of the spleen; bm compensates for the increase in plt
Splenomegaly
77
 normal: 1/3 of plt is sequestered in the spleen  inc: accumulation in the spleen → enlargement
Splenomegaly
78
asynchronous cell maturation resulting to abnormal cell size
Hypercellular maturation
79
abnormal development of cells within tissues or organs
Dysplasia
80
(no cell migration to the circulation leading to cytopenia)
Dysplasia
81
reduction/decrease in the number of mature blood cells
Cytopenia
82
abnormal increase in the number of a specified type of cells
Cytosis
83
form of programmed cell death
Apoptosis
84
From a hypercellular bone marrow→ Dysplasia→ Cytopenia of one or more cell line
Myelodysplastic Syndromes
85
Due to predomination of apoptosis.
Myelodysplastic Syndromes
86
From a hypercellular bone marrow→ Cytosis of all cell line
Myeloproliferative Disorders
87
The proliferation outpaces apoptosis
Myeloproliferative Disorders

Hematology 2 Lec (29 decks)

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