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Hematology 2 Lec > MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME INTRO > Flashcards

MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME INTRO Flashcards

1
Q

Myelo:

A

bone marrow

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2
Q

Dysplastic:

A

abnormal cell devt

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3
Q

Proliferative:

A

excess production of cell

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4
Q

Hypercellular maturation in BM → dysplasia and cytopenia of one or more cell line

A

MYELODYSPLASTIC

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5
Q

Hypercellularity → cytosis of one cell line, usually myeloid lineage (WBCs)

A

MYELOPROLIFERATIVE

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6
Q

(uncontrolled proliferation)

A

MYELOPROLIFERATIVE

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7
Q

(effective/normal hematopoiesis but overproliferation of abnormal cells)

A

MYELOPROLIFERATIVE

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8
Q

(ineffective hematopoiesis; prominent feature)

A

MYELODYSPLASTIC

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9
Q

: tissue-producing cell

A

dysplasia

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10
Q

: ↓ circulating cells

A

cytopenia

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11
Q

↓ bm that produces the cell = ↓ blood produced = ↓ circ cells

A

MYELODYSPLASTIC

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12
Q

: ↑ circulating cells

A

cytosis

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13
Q

Hypercellular: production of blood cells (plt, rbc, wbc)

A

MYELODYSPLASTIC

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14
Q

Ex. Pronormoblast doesn’t mature to a normal mature rbc

A

MYELODYSPLASTIC

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15
Q

Cell lines: erythrocytic, megakaryocytic, myelocytic

A

MYELODYSPLASTIC

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16
Q

Predomination of apoptosis

A

MYELODYSPLASTIC

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17
Q

Proliferation outpaces apoptosis

A

MYELOPROLIFERATIVE

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18
Q

Etiology: unknown

A

MYELODYSPLASTIC

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19
Q

Etiology: mutation of gene

A

MYELOPROLIFERATIVE

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20
Q

↓ cell production

A

MYELODYSPLASTIC

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21
Q

↑ cell production

A

MYELOPROLIFERATIVE

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22
Q

Dysplasia - Ineffective hematopoiesis (bm is not produced effectively or dysplastic) = cytopenic

A

MYELODYSPLASTIC

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23
Q

Proliferation - Normal (effective) but excessive hematopoiesis with hypercellularity

A

MYELOPROLIFERATIVE

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24
Q

↑ cell death

A

MYELODYSPLASTIC

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25
Q

Rbc dies before 120 days

A

MYELODYSPLASTIC

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26
Q

Rate of apoptosis is more than the production rate of rbc

A

MYELODYSPLASTIC

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27
Q

↓cell death, ↑proliferation ≠ Homeostasis ; 1:2

A

MYELOPROLIFERATIVE

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28
Q

After 120 days, apoptotic cell increases as bm proliferates

A

MYELOPROLIFERATIVE

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29
Q

Cell proliferates priod to apoptosis = cytosis

A

MYELOPROLIFERATIVE

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30
Q

Precursor diseases prior to anemia (↓rbc) and leukemia (↓wbc)

A

MYELODYSPLASTIC
MYELOPROLIFERATIVE

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31
Q

Premalignant disease

A

MDS

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32
Q

Malignant disease

A

CMPD

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33
Q

One or more cell lines are dysplastic

A

MDS

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34
Q

All cell lines are dysplastic

A

CMPD

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35
Q

Bone marrow cellularity is slightly increased

36
Q

Cellularity is markedly increased

37
Q

Peripheral cytopenia of one or more cell lines

38
Q

Peripheral cytosis of one cell line

39
Q

Iron stores are often increased

40
Q

Iron is normal or decreased

41
Q

No bone marrow fibrosis

42
Q

Marrow fibrosis is a prominent feature

43
Q

No megakaryocyte increase in the bone marrow

44
Q

Often increased numbers of megakaryocyte

45
Q

Splenomegaly is not a feature

46
Q

Splenomegaly is a frequent feature

47
Q

a premalignant process (preleukemic)

48
Q

a malignant disease

49
Q

one or more cell lines are dysplastic

50
Q

all cell lines are malignant

51
Q

usually slightly increased

52
Q

usually markedly increased

53
Q

peripheral cytopenia of one or more cell lines

54
Q

peripheral cytosis of usually one cell line

55
Q

dysplasia of one or more cell lines

56
Q

morphologically usually normal

57
Q

Iron stores often increased

58
Q

Iron stores normal or decreased

59
Q

Bone marrow fibrosis usually none

60
Q

Bone marrow fibrosis is a prominent feature in the course of disease

61
Q

Megakaryocyte population usually no increase in the bone marrow

62
Q

Megakaryocyte population often increased numbers

63
Q

Splenomegaly is not a feature

64
Q

Splenomegaly is not a feature but a frequent feature

65
Q

 Occurs before leukemia

66
Q

 rbc: dysplastic
 wbc, plt: normal

67
Q

 rbc (erythricytosis), wbc (leucocytosis), and plt (megakaryocytosis)

68
Q

 incorporated in rbc to make heme

69
Q

 ↓ rbc = is not used, but increases in the circulation

70
Q

 Accumulation of iron

71
Q

 ↑cell production requires more iron

72
Q

 Due to absence of cells

73
Q

 Cells produced inserts themselves in the sinusoids of bm esp in saturated circulation

74
Q

infiltration of cells in the bm, including the sinusoids, normal or abnormal cells

A

Bone marrow fibrosis

75
Q

 no space for circulation : very infiltrated

76
Q

Enlargement of the spleen; bm compensates for the increase in plt

A

Splenomegaly

77
Q

 normal: 1/3 of plt is sequestered in the spleen
 inc: accumulation in the spleen → enlargement

A

Splenomegaly

78
Q

asynchronous cell maturation resulting to abnormal cell size

A

Hypercellular maturation

79
Q

abnormal development of cells within tissues or organs

80
Q

(no cell migration to the circulation leading to cytopenia)

81
Q

reduction/decrease in the number of mature blood cells

82
Q

abnormal increase in the number of a specified type of cells

83
Q

form of programmed cell death

84
Q

From a hypercellular bone marrow→ Dysplasia→ Cytopenia of one or more cell line

A

Myelodysplastic Syndromes

85
Q

Due to predomination of apoptosis.

A

Myelodysplastic Syndromes

86
Q

From a hypercellular bone marrow→ Cytosis of all cell line

A

Myeloproliferative Disorders

87
Q

The proliferation outpaces apoptosis

A

Myeloproliferative Disorders

Hematology 2 Lec (29 decks)

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