Sclerosing disorders

Question 1

Category

Answer 1

Proliferative breast disease without atypia

Question 2

Reflected by increased numbers of acini per lobule with central distortion and compression and peripheral dilation

Answer 2

Sclerosing adenosis

Keywords:

• increased numbers of acini per lobule – adenosis
• Syptoms of sclerosis

Question 3

Have components of sclerosing adenosis, papillomas and epithelial hyperplasia

Answer 3

Complex sclerosing lesions

• Summary:*
• Sclerosis plus other fibrocystic changes

Question 4

Clinical significance

Answer 4

Mimics cancer on examination, on mammogramand gross pathologic examination

Question 5

Histopath finding

• Sclerosing adenosis
• Complex sclerosing lesions

Answer 5

• Sclerosing adenosis
  
  • Cords and sheets of cells within a sclerotic/fibrotic stroma
• Complex sclerosing lesions
  
  • Central nidus of entrapped glands within a hyalinized stroma, with fibrocystic changes and epithelial hyperplasia on adjacent areas

Question 6

35/F. Biopsy showed central nidus of entrapped glands within a hyalinized stroma, with fibrocystic changes and epithelial hyperplasia on adjacent areas. What is the diagnosis?

Answer 6

Complex sclerosing lesion/radial scar

Question 7

37/F. Biopsy showed cords and sheets of cells within a sclerotic stroma, with dilated ducts at the periphery. Immunohistochemistry: p63, CK5,6 (+). What is the diagnosis?

Answer 7

Sclerosing adenosis

Question 8

Malignant potential

Answer 8

None