Lobular carcinoma in situ (LCIS)

Question 1

Presentation

Answer 1

• Incidental on biopsy
• Usually no clinical signs

Question 2

Properties

• Basement membrane
• Disruption of lobules
• Papillary, cribriform patterns
• Necrosis and secretory activities
• Types
• Involvement of nipple skin
• Bilaterality
• Hormonal status

Answer 2

• Basement membrane
  
  • Intact
• Disruption of lobules
  
  • No
• Papillary, cribriform patterns
  
  • No
• Necrosis and secretory activities
  
  • Usually absent, thus negative calcification
• Types
  
  • High-grade
• Involvement of nipple skin
  
  • No
• Bilaterality
  
  • 20 to 40%
• Hormonal status
  
  • ER, PR ⊕; HER2 ⊝

Memory aid:

• Intact BM because it is not invasive
• It may seem counterintuitive but LCIS does not disrupt lobule

Question 3

LCIS develops only in the female breast

Answer 3

True; extremely rare finding in males due to the lack of lobular development in the male breast

Question 4

Is this a risk factor or a precursor to invasive breast cancer?

Answer 4

Risk factor