Schizoprenia

Question 1

What is schizophrenia?

Answer 1

Severe mental disorder that affects the way you think, emotions, language, sense of self and behavior

Question 2

What neurotransmitter causes schizophrenia and what does it do?

Answer 2

Dopamine- abnormal activity of it at D2 receptor in brain causes schizophrenia

Question 3

List the positive symptoms?

Answer 3

Hallucinations
Delusions
Thought disorder
Movement disorder

Question 4

List the negative symptoms?

Answer 4

Lack of motivation
Social withdrawal
Neglect of personal hygiene
Anhedonia and apathy

Question 5

What are the treatments used?

Answer 5

First gen antipsychotics(Typicals) - more positive symptoms

Second gen (Atypical) - both positive and negative

Question 6

First gen are more likely to cause what?

Answer 6

Extrapyramidal side effects (parkinsonism, dystonia, akathisia, tardive dyskinesia)

Question 7

Second gen can cause?

Answer 7

Metabolic side effects (weight gain, diabetes, dyslipidemia)

Question 8

List examples of 1st gen?

Answer 8

Prochlorperazine
Chlorpromazine
Haloperidol
Promazine
Sulpiride
Zuclopenthixol

Question 9

List examples of 2nd gen

Answer 9

Olanzapine
Quetiapine
Clozapine
Aripiprazole
Risperidone
Amisulpride

Question 10

What is the monitoring requirement for weight?

Answer 10

Monitor first 6 weeks then 12 weeks then annually

Question 11

What is the monitoring requirement for pulse/bp, Fg, hba1c?

Answer 11

12 weeks then annually

Question 12

What is the monitoring requirement for prolactin

Answer 12

Start of therapy
Then 6 months
Then annually

Question 13

What do you give for people that haven’t responded to antipsychotics?

Answer 13

Clozapine

Question 14

What is the leucocyte and blood count monitoring requirement for clozapine

Answer 14

Monitor every week for the first 18 weeks then every two weeks for a year then monthly

Question 15

What’s the fasting blood glucose monitoring requirement for clozapine?

Answer 15

Measure before therapy then after one then every 4-6 months after

Question 16

What is the blood lipids and weight monitoring requirement for clozapine?

Answer 16

Monitor initially then every 3 months in the first year then yearly

Question 17

List additional monitoring of clozapine

Answer 17

Stop smoking and move to e-cigarettes

Interactions that will increase clozapine level

Presence of pneumonia or serious infection

Reduced metabolism

Toxicity

Question 18

Which antipsychotics has highest incidence of wright gain

Answer 18

Clozapine and olanzapine

Question 19

what other antipsychotics causes weight gain

Answer 19

Quietiapine
Risperidone
Chlorpromazine

Question 20

Which drug causes hyperprolactinemia?

Answer 20

Mainly first gen - chlorpromazine

Question 21

What antipsychotics do not increase prolactin?

Answer 21

Clozapine
Olanzapine
Quetiapine
Aripiprazole

Question 22

What is neuroleptic malignant syndrome

Answer 22

Fatal severe adverse effect you get when using antipsychotics

Question 23

What are the Symptoms of NMS

Answer 23

Fever
Rigidity
Confusion
Inc sweating

Question 24

List the symptoms of NMS

Answer 24

Fever
Increased sweating
Rigidity
Confusion

Question 25

What can you use to rest NMS?

Answer 25

Dantrolene
Bromocriptine