Parkinson Disease Flashcards
Definition?
Neurodegenerative condition due to loss of dopamine cell of the substantia nigra
What are the motor symptoms
Rigidity
Bradykinesia - slow movement
Tremor
Postural instability
What are the non motor symptoms
Dementia
Depression
Sleep disturbance
Cognitive impairment
Loss of smell
What is the pharmacological treatment for managing motor symptoms?
Levodopa
What is Levodopa given with?
Dopa decarvoxylase inhibitor as co- careldopa or co-benaldopa
What motor complication can you get when you’re on levodopa?
Dyskinesia (unusual movement, like shaking and other stuff)
What’s the second/third line treatment?
Non ergotic dopamine receptor agonist
Mono amine oxidase b inhibitors
List examples of Non-ergotic dopamine receptor agonist?
RRAP
Pramipexole, ropinirole, rotigotine, apomorphine
Mimic actions of dopamine in brain
List examples of MAO-B inhibitors?
Rasagiline
Selegiline
When you’re taking MAOB inhibitors, they do not interact with what?
Tyramine rich foods (grapefruit, cheddar cheese, bacon, corned beef)
Which drugs can you use to increase levodopa therapy
COMT inhibitors (Entacapone and tolcapone)
List examples of ergot receptors and when do we use it?
Cabergoline, pergolide, bromocriptine
When the other class can’t control symptoms
What should be given as adjuvant therapy (if all the others fail) to reduce dyskinesia?
Amantadine
During off periods( when they can’t do anything at all) or freezing period (when a part of their body freezes), what is the best treatment?
Apomorphine
List the side effects you get when taking Apomorhine and what do you take to reduce it?
Domperidone (two days before starting treatment and stopped as soon as as possible)
