Schizophrenia Spectrum & Other Psychotic Disorders Flashcards

1
Q

Psychosis Definition

A

Profoundly out of touch with reality

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2
Q

Psychosis Criteria

A

Abnormalities in one of the following domains:

  • Delusions
  • Hallucinations
  • Disorganised thinking (speech) / Thought Disorder
  • Grossly disorganised or abnormal motor
  • Negative symptoms
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3
Q

Major Psychotic Disorders

DSM-V

A
  • Schizotypal (personality) disorder
  • Delusional Disorder
  • Brief Psychotic Disorder
  • Schizophreniform Disorder
  • Schizophrenia
  • Schizoaffective Disorder
  • Substance/Medication Induced Psychotic Disorder
  • Psychotic Disorder due to Another Medical Condition
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4
Q

Delusional Disorder Description and Types

A
  • Characterised by one month of delusions without other active-phase symptoms of schizophrenia
  • 7 Types
    Erotomanic, Grandiose, Jealousy, Persecutory, Somatic, Mixed and Unspecified
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5
Q

Brief Psychotic Disorder Description

A

A disorder that lasts more than a day and remits by 1 month

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6
Q

Schizophreniform Description

A

Characterised by a symptomatic presentation that is equivalent to schizophrenia except for its duration (the disturbance lasts for 1-6 months) and the absence of a requirement that there be a decline in functioning.

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7
Q

Schizoaffective Description

A

A mood episode and the active phase of schizophrenia occur together and were preceded or are followed by at least 2 weeks of delusions or hallucinations without prominent mood symptoms

  • Two types
    • Bipolar Type
    • Depressive Type
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8
Q

Schizophrenia Definition

A

Schizophrenia is characterised by the splitting of normal links between perception, mood, thinking, behaviour and contact with reality.

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9
Q

Schizophrenia Criteria

A
  • 2+ of the following, each present for a significant portion of time during a 1-month period (or less if successfully treated). At least one of the first three must be present
    1. Delusions
    2. Hallucinations
    3. Disorganised Speech (e.g. frequent derailments or incoherence)
    4. Grossly disorganised or catatonic behaviour
    5. Negative symptoms (i.e. diminished emotional expression or avolition)
  • Social/occupational dysfunction
  • Continuous signs of disturbance persist for at least 6 months
  • Schizoaffective and mood disorder exclusion (i.e. no manic or depressive episode)
  • Substance/medical condition exclusion
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10
Q

Schizophrenia Clinical Presentation

A
  • Positive symptoms
  • Negative symptoms
  • Cognitive impairment
  • Mood symptoms
  • Physical manifestations associated with schizophrenia
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11
Q

Positive Symptoms in Schizophrenia

A

Aspects of the illness that are added onto normal experience

  • Hallucinations
  • Delusions
  • Thought Disorganisation
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12
Q

Hallucinations in Schizophrenia

A
False sensory perceptions occurring in any of the five modalities
Types:
- Auditory (most common)
-- Music, voices or noises, there are the most responsive to medication
- Visual 
-- Glowing orbs or flashing lights
- Tactile or Somatic
-- Touching, sexual or pain
- Olfactory
- Gustatory (least common)
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13
Q

Delusions in Schizophrenia

A

Fixed false beliefs that are not typical of the patient’s culture.
Occurs in 80% of schizophrenics
Types:
- Grandiose
- Paranoid
- Erotomanic
– Belief in having a special relationship with someone that isn’t true
- Nihilistic
– Belief that one is dead or does not exist

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14
Q

Thought Disorganisation in Schizophrenia

A
Disruption of the logical process of thought may be represented by loose associations, nonsensical speech or bizarre behaviour
Types:
- Tangential Speech
- Circumstantial Speech
- Derailment
- Neologisms
-- The creation of new words
- Word Salad
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15
Q

Negative Symptoms in Schizophrenia

A

Things that are taken away from normal experience.
Types:
- Primary
- Secondary

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16
Q

Primary Negative Symptoms in Schizophrenia

A
Enduring negative symptoms are a core feature of schizophrenia (also known as deficit symptoms)
Types (4As):
- Affect flattening
- Alogia (decreased expressiveness)
- Apathy (indifference)
- Asociality/anhedonia
17
Q

Secondary Negative Symptom in Schizophrenia

A

May also be secondary to other manifestations of the illness or its treatment.
An example is : paranoia may lead to social isolation and depression to anergy (lack of energy)

18
Q

Cognitive Impairment in Schizophrenia

A
Most commonly; 
processing speed,
attention,
learning,
memory,
reasoning/executive functioning,
verbal comprehension
social cognition.
These symptoms are the reason why schizophrenics do poorly on neuropsychological assessment
19
Q

Mood and Anxiety Symptoms in Schizophrenia

A

The following symptoms are common:

  • Depression (25%)
  • Anxiety (38%)
20
Q

Associated Physical Manifestations in Schizophrenia

A
  • Neurological Disturbances
  • Catatonia
  • Metabolic Disturbances
21
Q

Neurological Disturbances in Schizophrenia

A

Most due to meds. Antipsychotic dopamine can cause extrapyramidal symptoms (EPS).
There are subtle impairments of sensory integration, motor coordination and sequencing

22
Q

Catatonia in Schizophrenia

A

Either:

  • Catatonic excitement
    • Excessive purposeless motor activity
  • Extreme negativism
    • Motiveless resistance or mutism
23
Q

Metabolic Disturbances in Schizophrenia

A

Schizophrenia has been associated with:

  • diabetes
  • hyperlipidaemia
  • HTN
24
Q

Schizophrenia Management

A

Pharmacological

  • Antipsychotics and titrate upwards
  • Clozapine and amisulpiride are more effective against the negative symptoms than other drugs
  • Benzodiazepine if sedation indicated

Psychological
- CBT is helpful at alleviating distress and disability as opposed to eliminating symptoms

Social Support
- Important for improved outcome

25
Q

Disease Stages

A
  1. Premorbid Phase
  2. Prodromal Phase
  3. First Onset of Psychosis
  4. Evolving Illness (5-10 years)
  5. Stable Illness (20 years)
26
Q

Schizophrenia Prognosis

A
  • 25% recover without relapse
  • 50% recover but relapse
  • 25% become chronic
  • 10% die by suicide (risk is greatest in the 1st year)