Medications Flashcards

1
Q

Psych Meds

Specific SSRI Drugs

A
Fluoxetine
Citalopram
Paroxetine
Sertraline
Fluvoxamine
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2
Q

Psych Meds

SSRI Mechanism of Action

A

Increase serotonin concentration by inhibiting the re-uptake of serotonin.

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3
Q

Psych Meds

SSRI Side Effects

A

Headache, hyponatraemia, anorexia, nausea, indigestion, sexual dysfunction.
Anxiety/agitation for first 1-2 weeks
Suicidal ideation

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4
Q

Psych Meds

Specific SNRI Drugs

A

Venlafaxine

Duloxetine

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5
Q

Psych Meds

SNRI Mechanism of Action

A

Increase NA concentration by inhibiting the re-uptake of NA

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6
Q

Psych Meds

SNRI Side Effects

A

Headache, anorexia, nausea, indigestion, sexual dysfunction. HTN/hypotension
Cardiotoxic in overdose

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7
Q

Psych Meds

Specific NaSSA Drugs

A

Mirtazapine

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8
Q

Psych Meds

NaSSA Mechanism of Action

A

NA and Specific Serotonin Antidepressant.

It acts centrally to increase release of NA and specific serotonin

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9
Q

Psych Meds

NaSSA Side Effects

A

Dry mouth, drowsiness and weight gain

Histamine agonist
Moderate adrenergic and muscarinic antagonist

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10
Q

Psych Meds

Specific TCA Drugs

A

Dothiepin
Imipramine
Amitriptyline
Lofepramine

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11
Q

Psych Meds

TCA Mechanism of Action

A

Inhibits NA (and some serotonin) re-uptake

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12
Q

Psych Meds

TCA Side Effects

A
Anticholinergic
- (dry mouth, urinary retention, confusion)
Antiadrenergic
- (Hypotension and impotence)
Cardiac Arrhythmias
Seizures
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13
Q

Psych Meds

Specific MAOI Drugs

A

Tranylcypromine

Phenelzine

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14
Q

Psych Meds

MAOI Mechanism of Action

A

Increases neurone excitability by inhibiting the uptake of neurotransmitters.

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15
Q

Psych Meds

MAOI Side Effects

A

Anticholinergic
- (dry mouth, urinary retention, confusion)
Antiadrenergic
- (Hypotension and impotence)
Tyramine Reaction
- Can cause fatal syndrome of HTN and throbbing headaches.
- From cheese and red wine

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16
Q

Psych Meds

SSRIs for Breast Feeding Mothers

A

Sertralline

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17
Q

Psych Meds

Types of Antidepressants

A
1st Line
- SSRIs
- SNRIs
- NaSSAs
2nd Line
- TCA
- MAOI
18
Q

Psych Meds

Types of Antipsychotics

A

Typical/First Generation

Atypical/Second Generation

19
Q

Psych Meds

Specific Typical Antipsychotics

A

Chlorpromazine
Haloperidol
Zuclopenthixol

20
Q

Psych Meds

Typical Antipsychotic Mechanism of Action

A

DA-receptor blocker, but also block cholinergic, adrenergic and histamine receptors

21
Q

Psych Meds

Specific Atypical Antipsychotics

A
Risperidone
Olanzapine
Quetiapine
Aripiprazole
Ziprazidone
Amisulpride
Paliperidone
Clozapine - 'Atypical' Atypical
22
Q

Psych Meds

Atypical Antipsychotic Mechanism of Action

A

Block 5HT2A <= D2 DA receptors.
Reduced efficacy on other receptors
Thus decreased EPS and increased metabolic syndrome than Typicals.

23
Q

Psych Meds

Efficacy of Typical and Atypical Antipsychotics

A
Positive Symptoms
- All moderate
Treatment Resistance
- No except clozapine does
Negative Symptoms & Cognitive Symptoms
- Limited except for limited-moderate for clozapine
24
Q

Psych Meds

Side Effects of Typical and Atypical Antipsychotics

A
Sedation
Weight Gain
Motor (including EPS)
Other
- Prolactin (typicals and respiradone)
- Clozapine
25
Q

Psych Meds

Dexamphetamine Description

A
  • Potent Psychostimulant
  • Short-acting
  • Promotes release of catecholamines (NA and DA)
26
Q

Psych Meds

Methyphenidate Description

A
  • Psychostimulant
  • Trade name - Ritalin
  • Long-acting
  • Increases DA
27
Q

Psych Meds

Types of Anticholinesterases

A

Donepezil
Rivastigmine
Galantamine

28
Q

Psych Meds

Antipsychotic Motor Side Effect Frequency

A
  • Typical - Common
  • Atypical - Less common
  • Clozapine - Rare
29
Q

Psych Meds

Antipsychotic Sedation Side Effect Frequency

A

Sedation

  • Typical - Less common
  • Atypical - Less common
  • Clozapine - Common
30
Q

Psych Meds

Clozapine Side Effect Profile

A
  • Agranulocytosis
  • Seizures
  • Myocarditis
31
Q

Psych Meds

Drug-Induced EPS Treatment

A
  • Neuroleptic-induced EPS -> Anticholinergic
  • Akathisia -> Beta blockers or benzodiazepines
  • Commonly used -> anticholinergic (benztropine)
32
Q

Psych Meds

Types of Mood Stabilisers

A

Lithium

Antiepileptics

  • Valproate
  • Lamotrigine
  • Carbamazepine

Atypical Antipsychotics
- Olanzapine

33
Q

Psych Meds

Lithium Mechanism of Action

A

Complex inhibition of signal pathways

34
Q

Psych Meds

Lithium Side Effects

A

Hypothyroidism, fine tremor, polyuria, polydipsia, weight gain, renal impairment, teratogen, cardiac defects

35
Q

Psych Meds

Valproate Mechanism of Action

A

Causes GABA increase and blocks Na Channels

36
Q

Psych Meds

Valproate Side Effects

A

Weight gain, sedation, NTD

37
Q

Psych Meds

Lamotrigine Mechanism of Action

A

Inactivates Na Channels

38
Q

Psych Meds

Lamotrigine Side Effects

A

Dizziness, sedation, skin rashes

39
Q

Psych Meds

Carbamazepine Mechanism of Action

A

Inactivates Na Channels

40
Q

Psych Meds

Carbamazepine Side Effects

A

Sedation, ataxia, blurred vision, water retention, hypersensitivity reactions, leucopenia, interacts with OCP (oral contraceptive pill)