Schizophrenia

Question 1

Pathology

Answer 1

Macroscopic pathological features of schizophrenia include:-

Ventricular enlargement
Reduced brain volume (up to 5%)
Reduced left planum temporale gray matter, and reversed planum temporale surface area asymmetry (normally left larger than right in a right handed person)

The most consistent microscopic findings have been a reduction of the size of the dorsolateral prefrontal cortex and the hippocampus.