Schizophrenia Flashcards
What is the DSM – 5?
The diagnostic and statistical manual of mental disorders 5th edition.
Criteria for the diagnosis and classification of various mental disorders.
FGAs are called & names?
Typical antipsychotics are thought to work almost exclusively through d2 antagonism
Chlorpromazine, Thioridazine, perphenazine, loxapine, haloperidol, fluphenazine, trifluperazine, thiothixene
What is the EPS risk of chlorpromazine and thioridazine?
Low
What is the EPS risk of haloperidol, fluphenazine, trifluperazine, thiothixene
High
Info
It has been demonstrated that 65% to 70% occupancy of D2 receptors is associated with antipsychotic response
80% occupancy and higher is associated with EPS
What is EPS?
Extrapyramidal symptoms such as dystonia, Pseudoparkinsonism, akathisia, and Tardive dyskinesia.
Chlorpromazine and Thioridazine have less EPS because they have less affinity to D2 receptors but more
Anti-cholinergic receptor activity. So therefore the risk of sedation and secondary cognitive impairment
What are atypical antipsychotics?
SGAs have more potent antagonism at serotonin 5 – HT and reduced binding affinity for D2 receptors. Which reduces the risk of EPS.
SGAs have a high potential for metabolic adverse effects
such as weight gain, lipid abnormalities, glucose abnormalities, and even diabetes
What are the names of the SGAs?
Olanzapine, quetiapine, Risperidone, ziprasidone
Major side effect of olanzapine?
Weight gain
Risperidone side effects?
Increase in prolactin
Metabolic risks with clozapine and olanzapine?
Weight gain, hyperglycemia, Dyslipidemia
Metabolic risks with Abilify, Geodon, Saphris, Latuda?
Low weight gain, low hyperglycemia, low dyslipidemia
Chlorpromazine metabolic risks?
High weight gain, high hyperglycemia, high dyslipidemia
