Miscellaneous drug question

Question 1

Loperamide dosing -

Answer 1

Initial 4 mg, followed by 2 mg after each loose stool up to 16 mg/day

Question 2

Metformin dosing recommendations?

Answer 2

80 years or older do not initiate unless renal dysfunction has been ruled out.
Renal disease or dysfunction serum creatinine greater than or equal to 1.5 mg/dL males or 1.4 mg/dl females
Liver disease