schizophrenia Flashcards
Define psychosis
a form of severe mental disturbance where the individual loses touch with reality
Schneider 1st Rank symptoms
ABCD:
- Auditory hallucinations
- Broadcasting of thoughts
- Controlled thoughts (delusions of control)
- Delusional perception
Positive/hard symptoms
- Hallucinations
- Delusions
- Bizarre behaviour
- Flight of ideas
Negative/soft symptoms
- Lack of facial expression (flat effect)
- Lack of pleasure (anhedonia)
- Lack of drive & energy (apathy)
- Lack of interest (avolitional)
- Lack of speech (alogia)
Types of delusional disorder
- Erotomania (stalkers)– believe that ppl are in love with them
- Paranoia
- Persecutory – usually comes from govt. or ppl with power
- Grandiose – believe that they are powerful
- Somatic – believe that they have alot of medical problems
- Morbid jealousy
Desc of schizoaffective disorder
- Major depressive episode + type A symptoms
- Delusions or hallucinations occur for at least 2 weeks
- The disturbance is NOT due to the direct physiologic effects of a substance eg. illicit drugs
Factors of schrizophrenia
1) Genetic
Eg. Unrelated: 0.86% chance
Children of 2 affected parents: 46.3%
2) Environmental
- Maternal viral infection / malnutrition
- Obstetric issues (using recreational drugs)
- Substance use especially cannabis
- Poverty
3) Brain structure & chemistry
- Associated with some imbalance of certain chemical sy
What can very high dose of Amphetamine cause?
- paranoia
- delusions
- auditory hallucinations
What block D2 receptors & alleviate positive/hard symptoms?
Phenothiazines (incl. chlorpromazine) & all other typical neuroleptics
Examples of 1st gen antipsychotics
Thorazine, Fluanxol & Haloperidol
Functions of 1st gen antipsychotics
- Effectively control +ve symptoms
- Primarily block dopamine receptors
Side effects of 1st gen antipsychotics
- Dry mouth
- Blurred vision
- Constipation
- Rigidity
- Tremors
- Restlessness
- Drowsiness
- Dizziness
Usually disappear a few weeks after patient starts treatment
Late-appearing side effect of 1st gen antipsychotics
Tardive dyskinesia
Examples of 2nd gen antipsychotics
- Abilify (aripiprazole)
- Risperdal (risperidone)
- Zyprexa (olanzapine)
- Seroquel (quetiapine)
- Clozaril (clozapine)
Functions of 2nd gen antipsychotics
- 1st line treatment
- excellent at reducing -ve symptoms