Scarring and Non-scarring hair loss & Excessive hair growth Flashcards
What is the anagen to telogen ratio in hair cycle physiology?
9:1
What is the duration of the anagen/growth phase?
~3 years
What is the duration of the catagen/regression phase?
1-2 weeks
What is the duration of the telogen/rest phase?
~3 months
What is the duration of the exogen/shedding phase?
~3 months
How is hair loss classified?
Diffuse or patchy, and scarring or non-scarring alopecia
What characterizes alopecia areata?
Chronic autoimmune disease with non-scarring round or oval bald patches
What is the pathophysiology of alopecia areata?
Own immune cells attack hairs in anagen phase, causing inflammation and hair loss
How does alopecia areata typically present?
Round/oval bald patches with smooth skin or short hair stubs
What is diffuse alopecia areata?
Overall hair thinning, uncommonly associated with alopecia areata
What is alopecia totalis?
Total loss of scalp hair
What is alopecia universalis?
Total loss of body hair
What is ophiasis in the context of alopecia areata?
Bandlike pattern of hair loss along occipital or temporal scalp margins
What are hallmark features of alopecia areata?
- Exclamation mark hairs
- White hair regrowth
- Nail pitting
What is the management approach for a single patch of alopecia areata?
No treatment, as there is an 80% chance of regrowth
What is the management for patchy alopecia areata?
- Intralesional injection/topical corticosteroids
- Minoxidil with localized PUVA therapy
What is the management for diffuse alopecia areata?
Diphencyprone contact immunotherapy
What is the mechanism of action for diphencyprone contact immunotherapy?
Induces contact dermatitis to distract the immune system from attacking hair follicles
What is the management for over 50% scalp hair loss in alopecia areata?
Systemic immunosuppressants, e.g., methotrexate
What is Trichotillomania?
Non-scarring, self-induced hair pulling.
What is the presentation of Trichotillomania?
Irregularly-shaped spiky patches with angular borders, containing random distribution of short, broken hair shafts and different-length hairs.
Where is Trichotillomania commonly distributed?
In areas that are easy to reach with hands, e.g., scalp, eyelashes, eyebrows.
What is the management for Trichotillomania?
Initial treatment of underlying psychogenic disorder in adults, followed by behavioral therapy, e.g., habit reversal and conservative ways to stop hair pulling, e.g., wearing gloves or putting socks on child’s hand, cutting hair close to scalp.
What is Androgenic alopecia?
Non-scarring hair thinning due to excess androgen levels, especially dihydrotestosterone (DHT) and genetic factors.