(SBI4U1) The Endocrine System Flashcards
What does the endocrine system consist of?
Collection of glands
What do the endocrine glands secrete?
Hormones
What 2 systems maintain homeostasis?
Endocrine
Nervous
What signals the release of hormones from endocrine glands?
Nervous System
Difference between endocrine and nervous signals (2)
Endocrine: Slower acting, longer lasting
Nervous: Fast acting, transient
What are hormones?
Chemicals produced in the body that regulate the activity of cells/organs
Where are hormones secreted?
Specialized glands (thyroid, pancreas etc.)
Hormones travel through the ___________ to affect ______ _____ by binding to _________
Bloodstream
Target cells
Receptors
The secretion of most hormones are regulated by what mechanism?
Negative-Feedback Mechanism
What are the major endocrine glands? (7)
Hypothalamus/Pituitary Thyroid Gland Adrenal Glands Pancreas Pineal Gland Parathyroid Gland Gonads (testes/ovaries)
____________ receives inputs from the _______ system and releases ________ to control the __________ gland
Hypothalamus
Nervous
Hormones
Pituitary
What are the two major lobes of pituitary gland?
Anterior
Posterior
What are the hormones released by the Posterior Pituitary? (2)
ADH
Oxytocin
What does ADH stand for?
Anti-Diuretic Hormone
What is the function of ADH?
Regulates fluid balance in body
What is the function of oxytocin? (2)
Triggers uterine muscle contractions during child birth
Stimulates breast milk production
Increased ADH = Decreased _____ ______
Urine volume
What are the hormones released by the anterior pituitary? (7)
TSH ACTH FSH LH HGH PRL Endorphins
What does TSH stand for?
Thyroid Stimulating Hormone
What does ACTH stand for?
Adrenocorticotropic Hormone
What does FSH stand for?
Follicle Stimulating Hormone
What does LH stand for?
Luteinizing Hormone
What does HGH stand for?
Human Growth Hormone
What does PRL stand for?
Prolactin
What does TSH do? (2)
Stimulates thyroid to grow
Stimulates thyroid to secrete thyroid hormones
What does ACTH do?
Stimulates the adrenal cortex to release hormones in response to stress
What does FSH do? (2)
In females: stimulates egg development and secretion of sex hormones
In males: stimulates sperm production
What does LH do? (2)
In females: regulates ovulation
In males: regulates secretion of sex hormones
What does HGH do?
Stimulates growth of bones and soft tissues
What does PRL do?
Stimulates breast development and milk production
What does endorphins do?
Neurotransmitters, act as natural pain killers
Adrenal glands are located where?
On top of each kidney
What do adrenal glands do?
Release hormones to respond to stress
____ stimulates the adrenal ______ in long term stress
ACTH
Cortex
___________ ______ stimulates the adrenal _______ in short term stress
Sympathetic nerves
Medulla
What hormones are released by the adrenal cortex? (2)
Cortisol
Aldosterone
What hormones are released by the adrenal medulla?
Adrenaline
What happens what cortisol and aldosterone are released? (4)
Retention of sodium ions and water
Increased blood volume/pressure
Protein and fat converted to glucose
Immune cells suppressed
True of False:
The suppression of immune cells with the release of cortisol and aldosterone could lead to long term health effects
True
What stimulates the adrenal medulla to release hormones?
Sympathetic nerves
What happens when adrenaline is released? (2)
Glycogen converted to glucose
Increased blood pressure, heart rate, breathing rate, metabolic rate
What is the results of adrenaline called?
Fight or flight response
Regulation of Cortisol Production:
What triggers the adrenal cortex to make cortisol? Where is it from?
ACTH
Anterior pituitary
Regulation of Cortisol Production:
What triggers the anterior pituitary to release ACTH? Where is it from?
CRH
Hypothalamus
What stimulates the thyroid gland?
TSH
What does CRH stand for?
Corticotropin Releasing Hormone
What does the thyroid gland release when stimulated?
Thyroxine
Receptors for thyroxine is found on ____ ____ _____
Most body cells
What effects does thyroxine have? (2)
Increased metabolic rate (energy production) in cells
Increased oxygen consumption in cells
Where is the increased consumption of oxygen caused by thyroxine most prevalent? (4)
Heart
Liver
Kidney
Skeletal Muscle
What triggers the anterior pituitary to release TSH?
TRH
Where is TRH produced?
Hypothalamus
If metabolism rates are too ___, hypothalamus releases ___ triggering pituitary to release ___, triggering _______ to release _________
Low TRH TSH Thyroid Thyroxine
What is low levels of thyroxine known as?
Hypothyroidism
What is high levels of thyroxine known as?
Hyperthyroidism
What are the symptoms of hypothyroidism? (5)
Muscular weakness Constant fatigue Sensitivity to cold Slowed mental processes Poor memory Goitre Constant stimulation of thyroid by TSH
What is goitre and what causes it?
Increased size of the thyroid due to lack of iodine (needed to make thyroxine)
What are the symptoms of hyperthyroidism? (7)
Rapid forceful heartbeat Weight loss in spite of increased appetite Restlessness Anxiety Sleeplessness Profuse sweating Heat intolerance
What is the function of the pancreas?
Regulates glucose levels
What 2 hormones does the pancreas produce?
Insulin
Glucagon
Insulin and glucagon are ____________ hormones; they have ________ effects
Antagonistic
Opposing
What stimulates insulin secretion? What secretes insulin?
What does insulin do?
High blood glucose levels
Beta cells
Converts glucose to glycogen to be stored in the liver
What stimulates glucagon secretion? What secretes glucagon?
What does glucagon do?
Low blood glucose levels
Alpha cells
Causes breakdown of glycogen and cellular release of glucose into blood
What disease is characterized by a high blood glucose level caused by problems with insulin production and/or action?
Diabetes
Why does Type 1 diabetes occur? How is it treated?
Occurs because the islet cells in the pancreas do not produce any insulin
Treated by injections of insulin
Why does Type 2 diabetes occur? How is it treated?
Occurs from reduced insulin production and/or the inability of insulin to bind to its receptors properly.
Treated by controlling diet and exercise
What is type 1 diabetes also known as?
Juvenile diabetes
What hormone does the pineal gland secrete?
Melatonin
What is the secretion of melatonin based on?
Amount of light
Low light = ____ melatonin
Increased light = ____ melatonin
More
Less
What does melatonin do? (3)
Regulates sleep cycle
Inhibits release of gonadotropins in young children (inhibits onset of puberty)
May act as an antioxidant and neuroprotective agent
More melatonin = ____ sleepy
More
What does the parathyroid gland regulate?
Calcium levels in the blood
Parathyroid gland releases ___________ hormone in response to low _______ ______
Parathyroid
Calcium levels
How many targets does the parathyroid hormone have? What are they?
3 targets:
Bones
Kidney
Intestines
What does the parathyroid hormone do to bones?
Stimulates osteoclasts to break down bone, releasing calcium
What does the parathyroid hormone do to the kidneys?
Stimulates reabsorption of calcium from nephron into the blood
What does the parathyroid hormone do to the intestines?
Increased absorption of calcium into the blood occurs due to elevated vitamin D levels
What are the gonads of males? What are the gonads of females?
Males: Testes
Females: Ovaries
The gonads are the primary source of what?
Sex hormones
What are the three types of sex hormones?
Androgen
Estrogen
Progestin
True or False:
Both males and females produce all three types of sex hormones
True
What is the predominant sex hormone in males?
Androgen
What are the predominant sex hormones females?
Estrogen and progestin
What is the primary sex hormone in males?
Testosterone
What is the primary sex hormone in females?
Estrogen
Testosterone and estrogen control what? (2)
Development of the secondary sexual characteristics
Sex drive
In males:
At the onset of puberty the hypothalamus secretes what?
GnRH (Gonadotropin-Releasing Hormone)
In males:
What does the GnRH do?
Stimulates the pituitary gland to release FSH(Follicle-Stimulating Hormone) and LH(Luteinizing Hormone)
In males:
What does FSH do?
Initiates sperm production
In males:
What does LH do?
Signals the release of testosterone
In males:
What is testosterone responsible for? (6)
Secondary sex characteristics: Deepening of the voice Growth of facial and body hair Muscle development Beginnings of sex drive Sperm production in testes
What arises with rising levels of testosterone?
Increasing inhibin levels as a negative feedback system, inhibiting the release of GnRH, FSH, and LH
In females:
What does FSH do?
Stimulates the development of egg cells (ova), which develop in the follicles
In females:
What cells produce inhibin to inhibit FSH production?
Follicle cells
In females:
What does LH do? (3)
Plays a role in the development of ova, as well as in the
Induction of ovulation, and the
Stimulation of estrogen and progesterone production by the ovaries
In females:
What does estrogen do? (2)
Assists in endometrial regrowth, ovulation, and calcium absorption
Responsible for secondary sex characteristics (breast development, growth of body hair, widening of the pelvis, development of sex drive)
In females:
What does progesterone do?
Assists in endometrial regrowth and inhibition of FSH and LH release
During middle age, the ovaries become ____ sensitive to ___ and __ and, therefore, cease to ______ follicles and undergo _________. What is this known as?
Less FSH LH Mature Ovulation Menopause