Sars-CoV-2

Question 1

What type of virus is coronavirus/Sars-CoV-2?

Answer 1

Coronaviridae

Question 2

Structure of coronavirus

Answer 2

Large, enveloped, pleomorphism particles with arrangement of spikes projecting from surface

Spike (S) glycoproteins surface antigen - for entry to cells

Question 3

What surface antigens does coronavirus have?

Answer 3

Spike (S) glycoprotein

Question 4

What do the spike glycoproteins surface antigens on coronavirus do?

Answer 4

Require for entry into cells

Question 5

How does coronavirus enter cells?

Answer 5

1- spike glycoproteins surface antigens bind to ACE2 transmembrane protein receptor
2- invagination of membrane
3- formation of endocytosis vesicle
4- release of virion into cytoplasm

Entry via receptors mediated endocytosis

Question 6

Diagnosis of covid-19

Answer 6

Nasopharyngeal swab -
LFT - detect amount of virus
PCR - detects viral RNA

Question 7

Transmission of coronavirus

Answer 7

Respiratory
e.g. coughing, sneezing, inhaling

• small article aerosols in air
• direct contact with larger particles or droplets
• indirect contact of viral particles on surfaces

Question 8

What is COVID-19?

Answer 8

A acute viral infection of respiratory tract