Sarcoidosis Flashcards
Two risk factors for sarcoidosis?
20-40
Female
Afro carribean
Typical description of person presenting with sarcoidosis?
35 y/o black female presenting with dry cough and SoB. She has erythema nodosum.
Name three extra-pulmonary manifestations of sarcoidosis
Liver- cirrhosis, liver nodules
Eyes- optic neuritis, conjunctivitis
Skin- erythema nodosum
Heart- cardiomyopathy
Kidneys- intersitial nephritis, kidney stones
Neuro- Peripheral and cranial polyneuropathy, encephalopathy
Bones- arthralgia, myopathy
Define sarcoidosis
granulomatous inflammatory condition with the potential to affect any organ in the body, but most commonly affects the lungs
Name a skin manifestation of sarcoidsosi
erythema nodosum
Name a palsy that occurs in sarcoidosis
Bell’s palsy
List three respiratory features of sarcoidosis
chest pain SoB dry cough reduced lung capacity pulmonary fibrosis pulmonary nodules
Two differential diagnoses for sarcoidosis?
TB lymphoma hypersensitivity pneumonitis HIV toxoplasmosis
What is the gold standard diagnostic test for sarcoidosis?
biopsy- bronchoscopy with US guidance
Name two key findings in the blood test of sarcoidosis patient
serum ACE
hypercalcaemia
Name two complications of sarcoidosis
pulmonary fibrosis
pulmonary hypertension
What is the prognosis of sarcoidosis?
60% spontaneously resolve within 6 months. Some patients may require lung transplants
Which type of inflammation arises in sarcoidosis?
non-necrotising granulomatous inflammation
Two key histological findings of sarcoidosis?
non-caseating granuloma with epitheliod cells
asteroid bodies
