Salmonella And Shigella Flashcards
Salmonella
Gram negative rod
Enterobacteriaciae
Typhoid
Septicemia
Acute Gastroenteritis
Typhoid Fever
Caused by A. S. Typhi
7-14 days incubation positive school
Episodic fever, bradycardia, skin rash (ROSE SPOTS), leukopenia, enlarged liver and spleen
Intestinal Hemorrhage
A. S. Typhi Pathogenesis
Infects via food or water
Bacterial induced endocytosis into epi cells
Survives inside macs
Goes into blood stream
Reinfected GI
S. Typhi Virulence Determinants
T3SS
Vi antigen
LPS
T3SS
Encoded in SPI-1
Type 3 secretion system
Injection needle
Pumps in effector proteins
A. S. Typhi Diagnosis
Week 1: positive stool
Week 2/3: positive blood, symptomatic
Week 3: Stool again
(Rose spots)
A. S. Typhi Treatment
Fluoroquinolones and Ceftriaxone
CHRONIC CARRIERS: Ampicillin or cipro OR surgery
A. S. Typhi Prevention
Control water supply and sewage disposal
Humans only host
Clean food
2 VACCINES
Oral attenuated and Vi capsular
C. S. Enteriditis and S. Typhimurium
Most common Salmonella in US
Diarrheal disease
- 8-48 hours after eating
- headache, chills, ab pain, vommiting, diarrhea, fever
- lasts 1-4 days
C. S. Enteriditis and S. Typhimurium Sources
Poultry, pork, eggs, dog food
Fruits vegetables
Pets (turtles and reptiles)
C. S. Enteriditis and S. Typhimurium Virulence Determinants
LPS
T3SS
Pertussis-like toxin
C. S. Enteriditis and S. Typhimurium Treatment
Self-limiting
Fluid and electrolytes
Antibiotics
Diagnosis of Salmonella
Culture feces or blood
POSITIVE for
-Glucose, H2S, Motile, Indole, Nitrate
NEGATIVE
-Oxidase, Lactose, Urease
Shigella
Dysenteriae most common developing world
Sonnet most common US
Sources 4Fs
-Food, Fingers, Feces, Flies
Low inoculum (100 bugs)
Shigella Disease
Fever (LPS)
Diarrhea,
ab cramps (Shiga Toxin)
HUS with Shigella Dysenteriae
